Cargando…

Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome

Psoriasis is a chronic inflammatory cutaneous disease, characterized by activated plasmacytoid dendritic cells, myeloid dendritic cells, Th17 cells, and hyperproliferating keratinocytes. Recent studies revealed skin-resident cells have pivotal roles in developing psoriatic skin lesions. The balance...

Descripción completa

Detalles Bibliográficos
Autor principal: Komine, Mayumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177330/
https://www.ncbi.nlm.nih.gov/pubmed/32276410
http://dx.doi.org/10.3390/ijms21072582
_version_ 1783525195186700288
author Komine, Mayumi
author_facet Komine, Mayumi
author_sort Komine, Mayumi
collection PubMed
description Psoriasis is a chronic inflammatory cutaneous disease, characterized by activated plasmacytoid dendritic cells, myeloid dendritic cells, Th17 cells, and hyperproliferating keratinocytes. Recent studies revealed skin-resident cells have pivotal roles in developing psoriatic skin lesions. The balance in effector T cells and regulatory T cells is disturbed, leading Foxp3-positive regulatory T cells to produce proinflammatory IL-17. Not only acquired but also innate immunity is important in psoriasis pathogenesis, especially in triggering the disease. Group 3 innate lymphoid cell are considered one of IL-17-producing cells in psoriasis. Short chain fatty acids produced by gut microbiota stabilize expression of Foxp3 in regulatory T cells, thereby stabilizing their function. The composition of gut microbiota influences the systemic inflammatory status, and associations been shown with diabetes mellitus, cardiovascular diseases, psychomotor diseases, and other systemic inflammatory disorders. Psoriasis has been shown to frequently comorbid with diabetes mellitus, cardiovascular diseases, psychomotor disease and obesity, and recent report suggested the similar abnormality in gut microbiota as the above comorbid diseases. However, the precise mechanism and relation between psoriasis pathogenesis and gut microbiota needs further investigation. This review introduces the recent advances in psoriasis research and tries to provide clues to solve the mysterious relation of psoriasis and gut microbiota.
format Online
Article
Text
id pubmed-7177330
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71773302020-04-28 Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome Komine, Mayumi Int J Mol Sci Review Psoriasis is a chronic inflammatory cutaneous disease, characterized by activated plasmacytoid dendritic cells, myeloid dendritic cells, Th17 cells, and hyperproliferating keratinocytes. Recent studies revealed skin-resident cells have pivotal roles in developing psoriatic skin lesions. The balance in effector T cells and regulatory T cells is disturbed, leading Foxp3-positive regulatory T cells to produce proinflammatory IL-17. Not only acquired but also innate immunity is important in psoriasis pathogenesis, especially in triggering the disease. Group 3 innate lymphoid cell are considered one of IL-17-producing cells in psoriasis. Short chain fatty acids produced by gut microbiota stabilize expression of Foxp3 in regulatory T cells, thereby stabilizing their function. The composition of gut microbiota influences the systemic inflammatory status, and associations been shown with diabetes mellitus, cardiovascular diseases, psychomotor diseases, and other systemic inflammatory disorders. Psoriasis has been shown to frequently comorbid with diabetes mellitus, cardiovascular diseases, psychomotor disease and obesity, and recent report suggested the similar abnormality in gut microbiota as the above comorbid diseases. However, the precise mechanism and relation between psoriasis pathogenesis and gut microbiota needs further investigation. This review introduces the recent advances in psoriasis research and tries to provide clues to solve the mysterious relation of psoriasis and gut microbiota. MDPI 2020-04-08 /pmc/articles/PMC7177330/ /pubmed/32276410 http://dx.doi.org/10.3390/ijms21072582 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Komine, Mayumi
Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome
title Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome
title_full Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome
title_fullStr Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome
title_full_unstemmed Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome
title_short Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome
title_sort recent advances in psoriasis research; the clue to mysterious relation to gut microbiome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177330/
https://www.ncbi.nlm.nih.gov/pubmed/32276410
http://dx.doi.org/10.3390/ijms21072582
work_keys_str_mv AT kominemayumi recentadvancesinpsoriasisresearchthecluetomysteriousrelationtogutmicrobiome