Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells—Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy

Various derivatives that mimic ceramide structures by introducing a triazole to connect the aminodiol moiety and long alkyl chain have been synthesized and screened for their anti-leukemia activity. SPS8 stood out among the derivatives, showing cytotoxic selectivity between leukemic cell lines and h...

Descripción completa

Detalles Bibliográficos
Autores principales: Chan, She-Hung, Leu, Wohn-Jenn, Swain, Sharada Prasanna, Hsu, Jui-Ling, Hou, Duen-Ren, Guh, Jih-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177546/
https://www.ncbi.nlm.nih.gov/pubmed/32252439
http://dx.doi.org/10.3390/ijms21072470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177546/
https://www.ncbi.nlm.nih.gov/pubmed/32252439
http://dx.doi.org/10.3390/ijms21072470

Ejemplares similares