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Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells—Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy

Various derivatives that mimic ceramide structures by introducing a triazole to connect the aminodiol moiety and long alkyl chain have been synthesized and screened for their anti-leukemia activity. SPS8 stood out among the derivatives, showing cytotoxic selectivity between leukemic cell lines and h...

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Detalles Bibliográficos
Autores principales:	Chan, She-Hung, Leu, Wohn-Jenn, Swain, Sharada Prasanna, Hsu, Jui-Ling, Hou, Duen-Ren, Guh, Jih-Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177546/ https://www.ncbi.nlm.nih.gov/pubmed/32252439 http://dx.doi.org/10.3390/ijms21072470

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