Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro‐β‐erythroidine in nicotine‐tolerant mice

OBJECTIVES: There is a long‐standing interest in developing nicotinic acetylcholine receptor (nAChR) antagonists for concomitant use with nAChR agonists (e.g., nicotine replacement) as complementary smoking cessation aids. Previous studies demonstrate that daily nicotine treatment confers tolerance...

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Detalles Bibliográficos
Autores principales: de Moura, Fernando B., Wilkerson, Jenny L., McMahon, Lance R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177571/
https://www.ncbi.nlm.nih.gov/pubmed/32092237
http://dx.doi.org/10.1002/brb3.1581

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