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Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study
BACKGROUND: Accumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism modified by nutrient intake, may contribute to the link between breastfeeding and child cogn...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177573/ https://www.ncbi.nlm.nih.gov/pubmed/32109009 http://dx.doi.org/10.1002/brb3.1579 |
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author | Taylor, Rachael M. Smith, Roger Collins, Clare E. Mossman, David Wong‐Brown, Michelle W. Chan, Eng‐Cheng Evans, Tiffany‐Jane Attia, John R. Buckley, Nick Drysdale, Karen Smith, Tenele Butler, Trent Hure, Alexis J. |
author_facet | Taylor, Rachael M. Smith, Roger Collins, Clare E. Mossman, David Wong‐Brown, Michelle W. Chan, Eng‐Cheng Evans, Tiffany‐Jane Attia, John R. Buckley, Nick Drysdale, Karen Smith, Tenele Butler, Trent Hure, Alexis J. |
author_sort | Taylor, Rachael M. |
collection | PubMed |
description | BACKGROUND: Accumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism modified by nutrient intake, may contribute to the link between breastfeeding and child cognition. The aim was to quantify the relationship between global DNA methylation and cognition and behavior at 4 years of age. METHODS: Child behavior and cognition were measured at age 4 years using the Wechsler Preschool and Primary Scale of Intelligence, third version (WPPSI‐III), and Child Behavior Checklist (CBC). Global DNA methylation (%5‐methylcytosines (%5mC)) was measured in buccal cells at age 4 years, using an enzyme‐linked immunosorbent assay (ELISA) commercial kit. Linear regression models were used to quantify the statistical relationships. RESULTS: Data were collected from 73 children recruited from the Women and Their Children's Health (WATCH) study. No statistically significant associations were found between global DNA methylation levels and child cognition or behavior (p > .05), though the estimates of effect were consistently negative. Global DNA methylation levels in males were significantly higher than in females (median %5mC: 1.82 vs. 1.03, males and females, respectively, (p < .05)). CONCLUSION: No association was found between global DNA methylation and child cognition and behavior; however given the small sample, this study should be pooled with other cohorts in future meta‐analyses. |
format | Online Article Text |
id | pubmed-7177573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71775732020-04-24 Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study Taylor, Rachael M. Smith, Roger Collins, Clare E. Mossman, David Wong‐Brown, Michelle W. Chan, Eng‐Cheng Evans, Tiffany‐Jane Attia, John R. Buckley, Nick Drysdale, Karen Smith, Tenele Butler, Trent Hure, Alexis J. Brain Behav Original Research BACKGROUND: Accumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism modified by nutrient intake, may contribute to the link between breastfeeding and child cognition. The aim was to quantify the relationship between global DNA methylation and cognition and behavior at 4 years of age. METHODS: Child behavior and cognition were measured at age 4 years using the Wechsler Preschool and Primary Scale of Intelligence, third version (WPPSI‐III), and Child Behavior Checklist (CBC). Global DNA methylation (%5‐methylcytosines (%5mC)) was measured in buccal cells at age 4 years, using an enzyme‐linked immunosorbent assay (ELISA) commercial kit. Linear regression models were used to quantify the statistical relationships. RESULTS: Data were collected from 73 children recruited from the Women and Their Children's Health (WATCH) study. No statistically significant associations were found between global DNA methylation levels and child cognition or behavior (p > .05), though the estimates of effect were consistently negative. Global DNA methylation levels in males were significantly higher than in females (median %5mC: 1.82 vs. 1.03, males and females, respectively, (p < .05)). CONCLUSION: No association was found between global DNA methylation and child cognition and behavior; however given the small sample, this study should be pooled with other cohorts in future meta‐analyses. John Wiley and Sons Inc. 2020-02-28 /pmc/articles/PMC7177573/ /pubmed/32109009 http://dx.doi.org/10.1002/brb3.1579 Text en © 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Taylor, Rachael M. Smith, Roger Collins, Clare E. Mossman, David Wong‐Brown, Michelle W. Chan, Eng‐Cheng Evans, Tiffany‐Jane Attia, John R. Buckley, Nick Drysdale, Karen Smith, Tenele Butler, Trent Hure, Alexis J. Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
title | Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
title_full | Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
title_fullStr | Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
title_full_unstemmed | Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
title_short | Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
title_sort | global dna methylation and cognitive and behavioral outcomes at 4 years of age: a cross‐sectional study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177573/ https://www.ncbi.nlm.nih.gov/pubmed/32109009 http://dx.doi.org/10.1002/brb3.1579 |
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