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Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway

Eleven novel isoquinoline-1-carboxamides (HSR1101~1111) were synthesized and evaluated for their effects on lipopolysaccharide (LPS)-induced production of pro-inflammatory mediators and cell migration in BV2 microglial cells. Three compounds (HSR1101~1103) exhibited the most potent suppression of LP...

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Detalles Bibliográficos
Autores principales:	Do, Ha Thi Thu, Bui, Bich Phuong, Sim, Seongrak, Jung, Jae-Kyung, Lee, Heesoon, Cho, Jungsook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177615/ https://www.ncbi.nlm.nih.gov/pubmed/32230861 http://dx.doi.org/10.3390/ijms21072319

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