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Activation of PKG and Akt Is Required for Cardioprotection by Ramelteon-Induced Preconditioning and Is Located Upstream of mKCa-Channels

Ramelteon is a Melatonin 1 (MT1)—and Melatonin 2 (MT2)—receptor agonist conferring cardioprotection by pharmacologic preconditioning. While activation of mitochondrial calcium-sensitive potassium (mK(Ca))-channels is involved in this protective mechanism, the specific upstream signaling pathway of R...

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Detalles Bibliográficos
Autores principales:	Torregroza, Carolin, Jalajel, Osameh, Raupach, Annika, Feige, Katharina, Bunte, Sebastian, Heinen, André, Mathes, Alexander, Hollmann, Markus W., Huhn, Ragnar, Stroethoff, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177737/ https://www.ncbi.nlm.nih.gov/pubmed/32276406 http://dx.doi.org/10.3390/ijms21072585

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