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Curcumin and Endometriosis
Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative str...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177778/ https://www.ncbi.nlm.nih.gov/pubmed/32244563 http://dx.doi.org/10.3390/ijms21072440 |
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author | Vallée, Alexandre Lecarpentier, Yves |
author_facet | Vallée, Alexandre Lecarpentier, Yves |
author_sort | Vallée, Alexandre |
collection | PubMed |
description | Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis. |
format | Online Article Text |
id | pubmed-7177778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71777782020-04-28 Curcumin and Endometriosis Vallée, Alexandre Lecarpentier, Yves Int J Mol Sci Review Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis. MDPI 2020-03-31 /pmc/articles/PMC7177778/ /pubmed/32244563 http://dx.doi.org/10.3390/ijms21072440 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vallée, Alexandre Lecarpentier, Yves Curcumin and Endometriosis |
title | Curcumin and Endometriosis |
title_full | Curcumin and Endometriosis |
title_fullStr | Curcumin and Endometriosis |
title_full_unstemmed | Curcumin and Endometriosis |
title_short | Curcumin and Endometriosis |
title_sort | curcumin and endometriosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177778/ https://www.ncbi.nlm.nih.gov/pubmed/32244563 http://dx.doi.org/10.3390/ijms21072440 |
work_keys_str_mv | AT valleealexandre curcuminandendometriosis AT lecarpentieryves curcuminandendometriosis |