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Curcumin and Endometriosis

Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative str...

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Detalles Bibliográficos
Autores principales: Vallée, Alexandre, Lecarpentier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177778/
https://www.ncbi.nlm.nih.gov/pubmed/32244563
http://dx.doi.org/10.3390/ijms21072440
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author Vallée, Alexandre
Lecarpentier, Yves
author_facet Vallée, Alexandre
Lecarpentier, Yves
author_sort Vallée, Alexandre
collection PubMed
description Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.
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spelling pubmed-71777782020-04-28 Curcumin and Endometriosis Vallée, Alexandre Lecarpentier, Yves Int J Mol Sci Review Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis. MDPI 2020-03-31 /pmc/articles/PMC7177778/ /pubmed/32244563 http://dx.doi.org/10.3390/ijms21072440 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vallée, Alexandre
Lecarpentier, Yves
Curcumin and Endometriosis
title Curcumin and Endometriosis
title_full Curcumin and Endometriosis
title_fullStr Curcumin and Endometriosis
title_full_unstemmed Curcumin and Endometriosis
title_short Curcumin and Endometriosis
title_sort curcumin and endometriosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177778/
https://www.ncbi.nlm.nih.gov/pubmed/32244563
http://dx.doi.org/10.3390/ijms21072440
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