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Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood

Undernutrition in early life may have a long consequence of type 2 diabetes in adulthood. The current study was aimed to explore the association between famine exposure in fetal life during China’s Great Famine (1959–1961) and dysglycemia in adulthood. The cross-sectional data from 7830 adults from...

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Autores principales: Zhang, Yan, Song, Chao, Wang, Meng, Gong, Weiyan, Ma, Yanning, Chen, Zheng, Feng, Ganyu, Wang, Rui, Fang, Hongyun, Fan, Jing, Liu, Ailing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177851/
https://www.ncbi.nlm.nih.gov/pubmed/32218356
http://dx.doi.org/10.3390/ijerph17072210
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author Zhang, Yan
Song, Chao
Wang, Meng
Gong, Weiyan
Ma, Yanning
Chen, Zheng
Feng, Ganyu
Wang, Rui
Fang, Hongyun
Fan, Jing
Liu, Ailing
author_facet Zhang, Yan
Song, Chao
Wang, Meng
Gong, Weiyan
Ma, Yanning
Chen, Zheng
Feng, Ganyu
Wang, Rui
Fang, Hongyun
Fan, Jing
Liu, Ailing
author_sort Zhang, Yan
collection PubMed
description Undernutrition in early life may have a long consequence of type 2 diabetes in adulthood. The current study was aimed to explore the association between famine exposure in fetal life during China’s Great Famine (1959–1961) and dysglycemia in adulthood. The cross-sectional data from 7830 adults from the 2010–2012 China National Nutrition and Health Surveillance was utilized. Participants who were born between 1960 and 1961 were selected as the exposed group, while the participants who were born in 1963 were selected as the unexposed group. Logistic regression was utilized to examine the relationship between fetal famine exposure and dysglycemia in adulthood. The prevalence of type 2 diabetes in the exposed and control group was 6.4% and 5.1%, respectively, and the risk of type 2 diabetes in the exposed group was 1.23 times higher than that of the control group (95%CI, 1.01–1.50; P = 0.042) in adulthood, and 1.40 times in the severely affected area (95%CI, 1.11–1.76; P = 0.004). The fasting plasma glucose of the exposed group was higher than that of the control group, which was only found in the severely affected area (P = 0.014) and females (P = 0.037). The association between famine and impaired fasting glucose was observed only in females (OR 1.31, 95%CI, 1.01–1.70; P = 0.040). Our results suggested that fetal exposure to Chinese famine increased the risk of dysglycemia in adulthood. This association was stronger in the severely affected area and females.
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spelling pubmed-71778512020-04-28 Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood Zhang, Yan Song, Chao Wang, Meng Gong, Weiyan Ma, Yanning Chen, Zheng Feng, Ganyu Wang, Rui Fang, Hongyun Fan, Jing Liu, Ailing Int J Environ Res Public Health Article Undernutrition in early life may have a long consequence of type 2 diabetes in adulthood. The current study was aimed to explore the association between famine exposure in fetal life during China’s Great Famine (1959–1961) and dysglycemia in adulthood. The cross-sectional data from 7830 adults from the 2010–2012 China National Nutrition and Health Surveillance was utilized. Participants who were born between 1960 and 1961 were selected as the exposed group, while the participants who were born in 1963 were selected as the unexposed group. Logistic regression was utilized to examine the relationship between fetal famine exposure and dysglycemia in adulthood. The prevalence of type 2 diabetes in the exposed and control group was 6.4% and 5.1%, respectively, and the risk of type 2 diabetes in the exposed group was 1.23 times higher than that of the control group (95%CI, 1.01–1.50; P = 0.042) in adulthood, and 1.40 times in the severely affected area (95%CI, 1.11–1.76; P = 0.004). The fasting plasma glucose of the exposed group was higher than that of the control group, which was only found in the severely affected area (P = 0.014) and females (P = 0.037). The association between famine and impaired fasting glucose was observed only in females (OR 1.31, 95%CI, 1.01–1.70; P = 0.040). Our results suggested that fetal exposure to Chinese famine increased the risk of dysglycemia in adulthood. This association was stronger in the severely affected area and females. MDPI 2020-03-25 2020-04 /pmc/articles/PMC7177851/ /pubmed/32218356 http://dx.doi.org/10.3390/ijerph17072210 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Yan
Song, Chao
Wang, Meng
Gong, Weiyan
Ma, Yanning
Chen, Zheng
Feng, Ganyu
Wang, Rui
Fang, Hongyun
Fan, Jing
Liu, Ailing
Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood
title Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood
title_full Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood
title_fullStr Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood
title_full_unstemmed Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood
title_short Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood
title_sort exposure to chinese famine in fetal life and the risk of dysglycemiain adulthood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177851/
https://www.ncbi.nlm.nih.gov/pubmed/32218356
http://dx.doi.org/10.3390/ijerph17072210
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