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Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro

Alpha-l-Locked nucleic acid (α-l-LNA) is a stereoisomeric analogue of locked nucleic acid (LNA), which possesses excellent biophysical properties and also exhibits high target binding affinity to complementary oligonucleotide sequences and resistance to nuclease degradations. Therefore, α-l-LNA nucl...

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Detalles Bibliográficos
Autores principales:	Raguraman, Prithi, Wang, Tao, Ma, Lixia, Jørgensen, Per Trolle, Wengel, Jesper, Veedu, Rakesh N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177859/ https://www.ncbi.nlm.nih.gov/pubmed/32244535 http://dx.doi.org/10.3390/ijms21072434

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