Cargando…

Benzylaminoethyureido-Tailed Benzenesulfonamides: Design, Synthesis, Kinetic and X-ray Investigations on Human Carbonic Anhydrases

A drug design strategy of carbonic anhydrase inhibitors (CAIs) belonging to sulfonamides incorporating ureidoethylaminobenzyl tails is presented. A variety of substitution patterns on the ring and the tails, located on para- or meta- positions with respect to the sulfonamide warheads were incorporat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ali, Majid, Bozdag, Murat, Farooq, Umar, Angeli, Andrea, Carta, Fabrizio, Berto, Paola, Zanotti, Giuseppe, Supuran, Claudiu T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177897/ https://www.ncbi.nlm.nih.gov/pubmed/32272689 http://dx.doi.org/10.3390/ijms21072560

Ejemplares similares

Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII
por: Gumus, Arzu, et al.
Publicado: (2022)

New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors
por: Combs, Jacob, et al.
Publicado: (2023)

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides
por: Abdoli, Morteza, et al.
Publicado: (2017)

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors
por: Abdoli, Morteza, et al.
Publicado: (2018)

Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria
por: Angeli, Andrea, et al.
Publicado: (2020)

Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationships
por: Fantacuzzi, Marialuigia, et al.
Publicado: (2023)

Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides
por: Angeli, Andrea, et al.
Publicado: (2023)

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry
por: Krasavin, Mikhail, et al.
Publicado: (2019)

Mycobacterium tuberculosisβ-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs
por: Aspatwar, Ashok, et al.
Publicado: (2019)

Inhibition of bacterial α-, β- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties
por: Angeli, Andrea, et al.
Publicado: (2018)

Benzenesulfonamides with different rigidity-conferring linkers as carbonic anhydrase inhibitors: an insight into the antiproliferative effect on glioblastoma, pancreatic, and breast cancer cells
por: Liguori, Francesco, et al.
Publicado: (2022)

A Class of 4-Sulfamoylphenyl-ω-aminoalkyl Ethers with Effective Carbonic Anhydrase Inhibitory Action and Antiglaucoma Effects
por: Bozdag, Murat, et al.
Publicado: (2014)

Polyamines and α-Carbonic Anhydrases
por: Scozzafava, Andrea, et al.
Publicado: (2016)

4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors
por: Abdoli, Morteza, et al.
Publicado: (2022)

Benzenesulfonamides Incorporating Hydantoin Moieties Effectively Inhibit Eukaryoticand Human Carbonic Anhydrases
por: Abdoli, Morteza, et al.
Publicado: (2022)

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors
por: Karioti, Anastasia, et al.
Publicado: (2016)

Mono- and di-thiocarbamate inhibition studies of the δ-carbonic anhydrase TweCAδ from the marine diatom Thalassiosira weissflogii
por: Bua, Silvia, et al.
Publicado: (2018)

In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos
por: Aspatwar, Ashok, et al.
Publicado: (2019)

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates
por: El-Gazzar, Marwa G., et al.
Publicado: (2018)

Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors
por: Peerzada, Mudasir Nabi, et al.
Publicado: (2023)

Amine- and Amino Acid-Based Compounds as Carbonic Anhydrase Activators
por: Angeli, Andrea, et al.
Publicado: (2021)

Multivalent Carbonic Anhydrases Inhibitors †
por: Carta, Fabrizio, et al.
Publicado: (2019)

Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies
por: Elkamhawy, Ahmed, et al.
Publicado: (2022)

Design, Synthesis and Biological Assessment of Rhodanine-Linked Benzenesulfonamide Derivatives as Selective and Potent Human Carbonic Anhydrase Inhibitors
por: Swain, Baijayantimala, et al.
Publicado: (2022)

4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies
por: Nada, Hossam, et al.
Publicado: (2022)

Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition
por: Mboge, Mam Y., et al.
Publicado: (2018)

Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies
por: Ferraroni, Marta, et al.
Publicado: (2022)

Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors
por: Oudah, Khulood H., et al.
Publicado: (2022)

Azidothymidine “Clicked” into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors
por: Berrino, Emanuela, et al.
Publicado: (2020)

Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide
por: El-Azab, Adel S., et al.
Publicado: (2022)

Tail-Approach-Based Design and Synthesis of Coumarin-Monoterpenes as Carbonic Anhydrase Inhibitors and Anticancer Agents
por: Zengin Kurt, Belma, et al.
Publicado: (2023)

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
por: Angeli, Andrea, et al.
Publicado: (2023)

Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani
por: Nocentini, Alessio, et al.
Publicado: (2019)

Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX
por: Peperidou, Aikaterini, et al.
Publicado: (2018)

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation
por: Anduran, Emilie, et al.
Publicado: (2020)

Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors
por: Angeli, Andrea, et al.
Publicado: (2023)

Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties
por: Tekeli, Tuba, et al.
Publicado: (2023)

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies
por: Aspatwar, Ashok, et al.
Publicado: (2018)

Synthetic Strategies and Computational Inhibition Activity Study for Triazinyl-Substituted Benzenesulfonamide Conjugates with Polar and Hydrophobic Amino Acids as Inhibitors of Carbonic Anhydrases
por: Mikulová, Mária Bodnár, et al.
Publicado: (2020)

Carbonic Anhydrase Activators. Part 19(1) Spectroscopic and Kinetic Investigations for the Interaction of Isozymes I and II With Primary Amines
por: Briganti, Fabrizio, et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_g4v0iuqks1ieuross8nvqrg8bq