MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has...

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Autores principales: Kooshkaki, Omid, Rezaei, Zohre, Rahmati, Meysam, Vahedi, Parviz, Derakhshani, Afshin, Brunetti, Oronzo, Baghbanzadeh, Amir, Mansoori, Behzad, Silvestris, Nicola, Baradaran, Behzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177921/
https://www.ncbi.nlm.nih.gov/pubmed/32276343
http://dx.doi.org/10.3390/ijms21072578
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author Kooshkaki, Omid
Rezaei, Zohre
Rahmati, Meysam
Vahedi, Parviz
Derakhshani, Afshin
Brunetti, Oronzo
Baghbanzadeh, Amir
Mansoori, Behzad
Silvestris, Nicola
Baradaran, Behzad
author_facet Kooshkaki, Omid
Rezaei, Zohre
Rahmati, Meysam
Vahedi, Parviz
Derakhshani, Afshin
Brunetti, Oronzo
Baghbanzadeh, Amir
Mansoori, Behzad
Silvestris, Nicola
Baradaran, Behzad
author_sort Kooshkaki, Omid
collection PubMed
description MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers.
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spelling pubmed-71779212020-04-28 MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers Kooshkaki, Omid Rezaei, Zohre Rahmati, Meysam Vahedi, Parviz Derakhshani, Afshin Brunetti, Oronzo Baghbanzadeh, Amir Mansoori, Behzad Silvestris, Nicola Baradaran, Behzad Int J Mol Sci Review MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers. MDPI 2020-04-08 /pmc/articles/PMC7177921/ /pubmed/32276343 http://dx.doi.org/10.3390/ijms21072578 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kooshkaki, Omid
Rezaei, Zohre
Rahmati, Meysam
Vahedi, Parviz
Derakhshani, Afshin
Brunetti, Oronzo
Baghbanzadeh, Amir
Mansoori, Behzad
Silvestris, Nicola
Baradaran, Behzad
MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers
title MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers
title_full MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers
title_fullStr MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers
title_full_unstemmed MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers
title_short MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers
title_sort mir-144: a new possible therapeutic target and diagnostic/prognostic tool in cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177921/
https://www.ncbi.nlm.nih.gov/pubmed/32276343
http://dx.doi.org/10.3390/ijms21072578
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