Cargando…
Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor neurons (MN). Importantly, MN degeneration is intimately linked to oligodendrocyte dysfunction and impaired capacity of oligodendrocyte precursor cells (OPCs) to regenerate the myelin sheath...
Autores principales: | Bonfanti, Elisabetta, Bonifacino, Tiziana, Raffaele, Stefano, Milanese, Marco, Morgante, Erica, Bonanno, Giambattista, Abbracchio, Maria P., Fumagalli, Marta |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177925/ https://www.ncbi.nlm.nih.gov/pubmed/32244295 http://dx.doi.org/10.3390/ijms21072395 |
Ejemplares similares
-
The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke
por: Bonfanti, Elisabetta, et al.
Publicado: (2017) -
Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression
por: Bonifacino, Tiziana, et al.
Publicado: (2019) -
The Physio-Pathological Role of Group I Metabotropic Glutamate Receptors Expressed by Microglia in Health and Disease with a Focus on Amyotrophic Lateral Sclerosis
por: Balbi, Matilde, et al.
Publicado: (2023) -
Blocking glutamate mGlu(5) receptors with the negative allosteric modulator CTEP improves disease course in SOD1(G93A) mouse model of amyotrophic lateral sclerosis
por: Milanese, Marco, et al.
Publicado: (2021) -
The Key Role of Astrocytes in Amyotrophic Lateral Sclerosis and Their Commitment to Glutamate Excitotoxicity
por: Provenzano, Francesca, et al.
Publicado: (2023)