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Impact of the Severities of Glaucoma on the Incidence of Subsequent Dementia: A Population-Based Cohort Study

The aim of the present study was to survey the relationship between the severity of glaucoma and subsequent dementia using the National Health Insurance Research Database (NHIRD) in Taiwan. Subjects with glaucoma were selected into the study group after an exclusion process, and each subject in the...

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Autores principales: Kuo, Fu-Hsuan, Chung, Jui-Fu, Hsu, Min-Yen, Lee, Chia-Yi, Huang, Jing-Yang, Hsieh, Ming-Ju, Yang, Shun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177931/
https://www.ncbi.nlm.nih.gov/pubmed/32252450
http://dx.doi.org/10.3390/ijerph17072426
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author Kuo, Fu-Hsuan
Chung, Jui-Fu
Hsu, Min-Yen
Lee, Chia-Yi
Huang, Jing-Yang
Hsieh, Ming-Ju
Yang, Shun-Fa
author_facet Kuo, Fu-Hsuan
Chung, Jui-Fu
Hsu, Min-Yen
Lee, Chia-Yi
Huang, Jing-Yang
Hsieh, Ming-Ju
Yang, Shun-Fa
author_sort Kuo, Fu-Hsuan
collection PubMed
description The aim of the present study was to survey the relationship between the severity of glaucoma and subsequent dementia using the National Health Insurance Research Database (NHIRD) in Taiwan. Subjects with glaucoma were selected into the study group after an exclusion process, and each subject in the study group was propensity score-matched to another non-glaucoma patient that constituted the control group. The Cox proportional hazard regression that considered multiple potential risk factors of dementia was used to yield the adjusted hazard ratios (aHR) of dementia in different severities of glaucoma. There were 1185 (5.63 percent) subjects in the study group and 1119 (5.32 percent) patients in the control group that developed dementia. After adjusting for multiple confounders, there were no differences in the rate of any dementia (aHR: 0.961, 95% CI: 0.886–1.043, p = 0.3443), vascular dementia (aHR: 0.928, 95% CI: 0.846–1.018, p = 0.1154), Alzheimer’s disease (aHR: 1.018, 95% CI: 0.761–1.362, p = 0.9025) or Parkinson’s disease (aHR: 1.021, 95% CI: 0.886–1.176, p = 0.7744) between the study and the control groups. Regarding the disease severity of glaucoma, no difference was found in any type of dementia whether the glaucoma patients received less than two medical treatments, received more than two medical treatments, received drainage surgeries or received destructive surgeries. In conclusion, the different severities of glaucoma do not alter the incidence of subsequent dementia.
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spelling pubmed-71779312020-04-28 Impact of the Severities of Glaucoma on the Incidence of Subsequent Dementia: A Population-Based Cohort Study Kuo, Fu-Hsuan Chung, Jui-Fu Hsu, Min-Yen Lee, Chia-Yi Huang, Jing-Yang Hsieh, Ming-Ju Yang, Shun-Fa Int J Environ Res Public Health Article The aim of the present study was to survey the relationship between the severity of glaucoma and subsequent dementia using the National Health Insurance Research Database (NHIRD) in Taiwan. Subjects with glaucoma were selected into the study group after an exclusion process, and each subject in the study group was propensity score-matched to another non-glaucoma patient that constituted the control group. The Cox proportional hazard regression that considered multiple potential risk factors of dementia was used to yield the adjusted hazard ratios (aHR) of dementia in different severities of glaucoma. There were 1185 (5.63 percent) subjects in the study group and 1119 (5.32 percent) patients in the control group that developed dementia. After adjusting for multiple confounders, there were no differences in the rate of any dementia (aHR: 0.961, 95% CI: 0.886–1.043, p = 0.3443), vascular dementia (aHR: 0.928, 95% CI: 0.846–1.018, p = 0.1154), Alzheimer’s disease (aHR: 1.018, 95% CI: 0.761–1.362, p = 0.9025) or Parkinson’s disease (aHR: 1.021, 95% CI: 0.886–1.176, p = 0.7744) between the study and the control groups. Regarding the disease severity of glaucoma, no difference was found in any type of dementia whether the glaucoma patients received less than two medical treatments, received more than two medical treatments, received drainage surgeries or received destructive surgeries. In conclusion, the different severities of glaucoma do not alter the incidence of subsequent dementia. MDPI 2020-04-02 2020-04 /pmc/articles/PMC7177931/ /pubmed/32252450 http://dx.doi.org/10.3390/ijerph17072426 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kuo, Fu-Hsuan
Chung, Jui-Fu
Hsu, Min-Yen
Lee, Chia-Yi
Huang, Jing-Yang
Hsieh, Ming-Ju
Yang, Shun-Fa
Impact of the Severities of Glaucoma on the Incidence of Subsequent Dementia: A Population-Based Cohort Study
title Impact of the Severities of Glaucoma on the Incidence of Subsequent Dementia: A Population-Based Cohort Study
title_full Impact of the Severities of Glaucoma on the Incidence of Subsequent Dementia: A Population-Based Cohort Study
title_fullStr Impact of the Severities of Glaucoma on the Incidence of Subsequent Dementia: A Population-Based Cohort Study
title_full_unstemmed Impact of the Severities of Glaucoma on the Incidence of Subsequent Dementia: A Population-Based Cohort Study
title_short Impact of the Severities of Glaucoma on the Incidence of Subsequent Dementia: A Population-Based Cohort Study
title_sort impact of the severities of glaucoma on the incidence of subsequent dementia: a population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177931/
https://www.ncbi.nlm.nih.gov/pubmed/32252450
http://dx.doi.org/10.3390/ijerph17072426
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