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The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression

Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage. Chondrocyte hypertrophy or chondrocyte senescence is thought to play a role in the initiatio...

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Autores principales: Rim, Yeri Alice, Nam, Yoojun, Ju, Ji Hyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177949/
https://www.ncbi.nlm.nih.gov/pubmed/32235300
http://dx.doi.org/10.3390/ijms21072358
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author Rim, Yeri Alice
Nam, Yoojun
Ju, Ji Hyeon
author_facet Rim, Yeri Alice
Nam, Yoojun
Ju, Ji Hyeon
author_sort Rim, Yeri Alice
collection PubMed
description Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage. Chondrocyte hypertrophy or chondrocyte senescence is thought to play a role in the initiation and progression of OA. Although chondrocyte hypertrophy and cell death are both crucial steps during the natural process of endochondral bone formation, the abnormal activation of these two processes after injury or during aging seems to accelerate the progression of OA. However, the exact mechanisms of OA progression and these two processes remain poorly understood. Chondrocyte senescence and hypertrophy during OA share various markers and processes. In this study, we reviewed the changes that occur during chondrocyte hypertrophy or senescence in OA and the attempts that were made to regulate them. Regulation of hypertrophic or senescent chondrocytes might be a potential therapeutic target to slow down or stop OA progression; thus, a better understanding of the processes is required for management.
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spelling pubmed-71779492020-04-28 The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression Rim, Yeri Alice Nam, Yoojun Ju, Ji Hyeon Int J Mol Sci Review Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage. Chondrocyte hypertrophy or chondrocyte senescence is thought to play a role in the initiation and progression of OA. Although chondrocyte hypertrophy and cell death are both crucial steps during the natural process of endochondral bone formation, the abnormal activation of these two processes after injury or during aging seems to accelerate the progression of OA. However, the exact mechanisms of OA progression and these two processes remain poorly understood. Chondrocyte senescence and hypertrophy during OA share various markers and processes. In this study, we reviewed the changes that occur during chondrocyte hypertrophy or senescence in OA and the attempts that were made to regulate them. Regulation of hypertrophic or senescent chondrocytes might be a potential therapeutic target to slow down or stop OA progression; thus, a better understanding of the processes is required for management. MDPI 2020-03-29 /pmc/articles/PMC7177949/ /pubmed/32235300 http://dx.doi.org/10.3390/ijms21072358 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rim, Yeri Alice
Nam, Yoojun
Ju, Ji Hyeon
The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
title The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
title_full The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
title_fullStr The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
title_full_unstemmed The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
title_short The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
title_sort role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177949/
https://www.ncbi.nlm.nih.gov/pubmed/32235300
http://dx.doi.org/10.3390/ijms21072358
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