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Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity

Obesity is one of the major social and health problems globally and often associated with various other pathological conditions. In addition to unregulated eating behaviour, circulating peptide-mediated hormonal secretion and signaling pathways play a critical role in food intake induced obesity. Am...

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Detalles Bibliográficos
Autores principales: Kumar, Ujendra, Singh, Sneha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177963/
https://www.ncbi.nlm.nih.gov/pubmed/32272767
http://dx.doi.org/10.3390/ijms21072568
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author Kumar, Ujendra
Singh, Sneha
author_facet Kumar, Ujendra
Singh, Sneha
author_sort Kumar, Ujendra
collection PubMed
description Obesity is one of the major social and health problems globally and often associated with various other pathological conditions. In addition to unregulated eating behaviour, circulating peptide-mediated hormonal secretion and signaling pathways play a critical role in food intake induced obesity. Amongst the many peptides involved in the regulation of food-seeking behaviour, somatostatin (SST) is the one which plays a determinant role in the complex process of appetite. SST is involved in the regulation of release and secretion of other peptides, neuronal integrity, and hormonal regulation. Based on past and recent studies, SST might serve as a bridge between central and peripheral tissues with a significant impact on obesity-associated with food intake behaviour and energy expenditure. Here, we present a comprehensive review describing the role of SST in the modulation of multiple central and peripheral signaling molecules. In addition, we highlight recent progress and contribution of SST and its receptors in food-seeking behaviour, obesity (orexigenic), and satiety (anorexigenic) associated pathways and mechanism.
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spelling pubmed-71779632020-04-28 Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity Kumar, Ujendra Singh, Sneha Int J Mol Sci Review Obesity is one of the major social and health problems globally and often associated with various other pathological conditions. In addition to unregulated eating behaviour, circulating peptide-mediated hormonal secretion and signaling pathways play a critical role in food intake induced obesity. Amongst the many peptides involved in the regulation of food-seeking behaviour, somatostatin (SST) is the one which plays a determinant role in the complex process of appetite. SST is involved in the regulation of release and secretion of other peptides, neuronal integrity, and hormonal regulation. Based on past and recent studies, SST might serve as a bridge between central and peripheral tissues with a significant impact on obesity-associated with food intake behaviour and energy expenditure. Here, we present a comprehensive review describing the role of SST in the modulation of multiple central and peripheral signaling molecules. In addition, we highlight recent progress and contribution of SST and its receptors in food-seeking behaviour, obesity (orexigenic), and satiety (anorexigenic) associated pathways and mechanism. MDPI 2020-04-07 /pmc/articles/PMC7177963/ /pubmed/32272767 http://dx.doi.org/10.3390/ijms21072568 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kumar, Ujendra
Singh, Sneha
Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity
title Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity
title_full Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity
title_fullStr Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity
title_full_unstemmed Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity
title_short Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity
title_sort role of somatostatin in the regulation of central and peripheral factors of satiety and obesity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177963/
https://www.ncbi.nlm.nih.gov/pubmed/32272767
http://dx.doi.org/10.3390/ijms21072568
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