Cargando…

The Number and Position of Orai3 Units within Heteromeric Store-Operated Ca(2+) Channels Alter the Pharmacology of I(CRAC)

Store-operated heteromeric Orai1/Orai3 channels have been discussed in the context of aging, cancer, and immune cell differentiation. In contrast to homomeric Orai1 channels, they exhibit a different pharmacology upon application of reactive oxygen species (ROS) or 2-aminoethoxydiphenyl borate (2-AP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kappel, Sven, Kilch, Tatiana, Baur, Roland, Lochner, Martin, Peinelt, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178029/ https://www.ncbi.nlm.nih.gov/pubmed/32252254 http://dx.doi.org/10.3390/ijms21072458

Ejemplares similares

Targeting CRAC channels in inflammatory bowel disease
por: Kappel, Sven, et al.
Publicado: (2022)

Regulation of Ca(2+) signaling in prostate cancer cells
por: Kilch, Tatiana, et al.
Publicado: (2016)

Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
por: Emrich, Scott M, et al.
Publicado: (2023)

The action of selective CRAC channel blockers is affected by the Orai pore geometry
por: Derler, Isabella, et al.
Publicado: (2013)

How Many Orai's Does It Take to Make a CRAC Channel?
por: Thompson, Jill L., et al.
Publicado: (2013)

Orai1 pore residues control CRAC channel inactivation independently of calmodulin
por: Mullins, Franklin M., et al.
Publicado: (2016)

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
por: Penna, Aubin, et al.
Publicado: (2008)

Correction: Orai1 pore residues control CRAC channel inactivation independently of calmodulin
por: Mullins, Franklin M., et al.
Publicado: (2016)

Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1
por: Maltan, Lena, et al.
Publicado: (2023)

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus
por: Derler, Isabella, et al.
Publicado: (2018)

Orai1 Mutations Alter Ion Permeation and Ca(2+)-dependent Fast Inactivation of CRAC Channels: Evidence for Coupling of Permeation and Gating
por: Yamashita, Megumi, et al.
Publicado: (2007)

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions
por: Tiffner, Adéla, et al.
Publicado: (2020)

Highlighting the Multifaceted Role of Orai1 N-Terminal- and Loop Regions for Proper CRAC Channel Functions
por: Humer, Christina, et al.
Publicado: (2022)

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation
por: Grieve, Adam G., et al.
Publicado: (2021)

Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells
por: Holzmann, Christian, et al.
Publicado: (2015)

ORAI1 Crac Channel in Immune Cell is a Therapeutic Target for Pancreatitis-Associated Acute Lung Injury
por: Peng, Shuang, et al.
Publicado: (2023)

Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits
por: Yen, Michelle, et al.
Publicado: (2018)

S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
por: Yu, Tao, et al.
Publicado: (2023)

Store-Operated Ca(2+) Entry as a Prostate Cancer Biomarker — a Riddle with Perspectives
por: Kappel, Sven, et al.
Publicado: (2017)

Regulation of Orai1/STIM1 mediated I(CRAC) by intracellular pH
por: Gavriliouk, D., et al.
Publicado: (2017)

Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells
por: Schild, Achille, et al.
Publicado: (2020)

Constitutive recycling of the store-operated Ca(2+) channel Orai1 and its internalization during meiosis
por: Yu, Fang, et al.
Publicado: (2010)

Structures reveal opening of the store-operated calcium channel Orai
por: Hou, Xiaowei, et al.
Publicado: (2018)

The Contribution of Orai(CRACM)1 and Orai(CRACM)2 Channels in Store-Operated Ca(2+) Entry and Mediator Release in Human Lung Mast Cells
por: Ashmole, Ian, et al.
Publicado: (2013)

Correction to: Store-Operated Ca(2+) Entry as a Prostate Cancer Biomarker — a Riddle with Perspectives
por: Kappel, Sven, et al.
Publicado: (2018)

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer
por: Holzmann, Christian, et al.
Publicado: (2013)

The elementary unit of store-operated Ca(2+) entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions
por: Luik, Riina M., et al.
Publicado: (2006)

2-Aminoethoxydiphenyl Borate Potentiates CRAC Current by Directly Dilating the Pore of Open Orai1
por: Xu, Xiaolan, et al.
Publicado: (2016)

Separation and Characterization of Currents through Store-operated CRAC Channels and Mg(2+)-inhibited Cation (MIC) Channels
por: Prakriya, Murali, et al.
Publicado: (2002)

A Novel Role of the TRPM4 Ion Channel in Exocytosis
por: Stokłosa, Paulina, et al.
Publicado: (2022)

Store-independent modulation of Ca(2+) entry through Orai by Septin 7
por: Deb, Bipan Kumar, et al.
Publicado: (2016)

TRP Channels in Digestive Tract Cancers
por: Stokłosa, Paulina, et al.
Publicado: (2020)

More Than Just Simple Interaction between STIM and Orai Proteins: CRAC Channel Function Enabled by a Network of Interactions with Regulatory Proteins
por: Berlansky, Sascha, et al.
Publicado: (2021)

The Role of Lipids in CRAC Channel Function
por: Maltan, Lena, et al.
Publicado: (2022)

CRAC channel inhibitors in pancreatic pathologies
por: Gerasimenko, Oleg V., et al.
Publicado: (2022)

Orai channels: key players in Ca(2+) homeostasis
por: Sallinger, Matthias, et al.
Publicado: (2020)

Single Channel Properties and Regulated Expression of Ca(2+) Release-Activated Ca(2+) (Crac) Channels in Human T Cells
por: Fomina, Alla F., et al.
Publicado: (2000)

Targeting Orai1-Mediated Store-Operated Ca(2+) Entry in Heart Failure
por: Luo, Rui, et al.
Publicado: (2020)

Complex role of STIM1 in the activation of store-independent Orai1/3 channels
por: Zhang, Xuexin, et al.
Publicado: (2014)

Sphingomyelin, ORAI1 channels, and cellular Ca(2+) signaling
por: Hogan, Patrick G.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_iaf26a2hg3g1t5hvk9utf8jf54