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Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity

Mouse models of alcohol use disorder (AUD) revealed purinergic P2X4 receptors (P2X4Rs) as a promising target for AUD drug development. We have previously demonstrated that residues at the transmembrane (TM)–ectodomain interface and within the TM1 segment contribute to the formation of an ethanol act...

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Detalles Bibliográficos
Autores principales:	Popova, Maya, Rodriguez, Larry, Trudell, James R., Nguyen, Sylvia, Bloomfield, Michael, Davies, Daryl L., Asatryan, Liana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178174/ https://www.ncbi.nlm.nih.gov/pubmed/32252459 http://dx.doi.org/10.3390/ijms21072471

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