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Curcumin and Colorectal Cancer: From Basic to Clinical Evidences
Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, and anti-angiogenic purposes. We conducted a literature review to summar...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178200/ https://www.ncbi.nlm.nih.gov/pubmed/32235371 http://dx.doi.org/10.3390/ijms21072364 |
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author | Pricci, Maria Girardi, Bruna Giorgio, Floriana Losurdo, Giuseppe Ierardi, Enzo Di Leo, Alfredo |
author_facet | Pricci, Maria Girardi, Bruna Giorgio, Floriana Losurdo, Giuseppe Ierardi, Enzo Di Leo, Alfredo |
author_sort | Pricci, Maria |
collection | PubMed |
description | Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, and anti-angiogenic purposes. We conducted a literature review to summarize studies investigating the relationship between curcumin and colorectal cancer (CRC). In vitro studies, performed on human colon cancer cell lines, showed that curcumin inhibited cellular growth through cycle arrest at the G2/M and G1 phases, as well as stimulated apoptosis by interacting with multiple molecular targets. In vivo studies have been performed in inflammatory and genetic CRC animal models with a chemopreventive effect. To improve curcumin bioavailability, it has been associated with small particles that increase its absorption when orally administered with excellent results on both inflammation and carcinogenesis. Curcumin has been used, moreover, as a component of dietetic formulations for CRC chemoprevention. These combinations showed in vitro and in vivo anticarcinogenetic properties in inflammation-related and genetic CRC. A synergic effect was suggested using an individual constituent dosage, which was lower than that experimentally used “in vivo” for single components. In conclusion, curcumin falls within the category of plant origin substances able to prevent CRC in animals. This property offers promising expectations in humans. |
format | Online Article Text |
id | pubmed-7178200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71782002020-04-28 Curcumin and Colorectal Cancer: From Basic to Clinical Evidences Pricci, Maria Girardi, Bruna Giorgio, Floriana Losurdo, Giuseppe Ierardi, Enzo Di Leo, Alfredo Int J Mol Sci Review Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, and anti-angiogenic purposes. We conducted a literature review to summarize studies investigating the relationship between curcumin and colorectal cancer (CRC). In vitro studies, performed on human colon cancer cell lines, showed that curcumin inhibited cellular growth through cycle arrest at the G2/M and G1 phases, as well as stimulated apoptosis by interacting with multiple molecular targets. In vivo studies have been performed in inflammatory and genetic CRC animal models with a chemopreventive effect. To improve curcumin bioavailability, it has been associated with small particles that increase its absorption when orally administered with excellent results on both inflammation and carcinogenesis. Curcumin has been used, moreover, as a component of dietetic formulations for CRC chemoprevention. These combinations showed in vitro and in vivo anticarcinogenetic properties in inflammation-related and genetic CRC. A synergic effect was suggested using an individual constituent dosage, which was lower than that experimentally used “in vivo” for single components. In conclusion, curcumin falls within the category of plant origin substances able to prevent CRC in animals. This property offers promising expectations in humans. MDPI 2020-03-29 /pmc/articles/PMC7178200/ /pubmed/32235371 http://dx.doi.org/10.3390/ijms21072364 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pricci, Maria Girardi, Bruna Giorgio, Floriana Losurdo, Giuseppe Ierardi, Enzo Di Leo, Alfredo Curcumin and Colorectal Cancer: From Basic to Clinical Evidences |
title | Curcumin and Colorectal Cancer: From Basic to Clinical Evidences |
title_full | Curcumin and Colorectal Cancer: From Basic to Clinical Evidences |
title_fullStr | Curcumin and Colorectal Cancer: From Basic to Clinical Evidences |
title_full_unstemmed | Curcumin and Colorectal Cancer: From Basic to Clinical Evidences |
title_short | Curcumin and Colorectal Cancer: From Basic to Clinical Evidences |
title_sort | curcumin and colorectal cancer: from basic to clinical evidences |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178200/ https://www.ncbi.nlm.nih.gov/pubmed/32235371 http://dx.doi.org/10.3390/ijms21072364 |
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