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Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, and anti-angiogenic purposes. We conducted a literature review to summar...

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Autores principales: Pricci, Maria, Girardi, Bruna, Giorgio, Floriana, Losurdo, Giuseppe, Ierardi, Enzo, Di Leo, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178200/
https://www.ncbi.nlm.nih.gov/pubmed/32235371
http://dx.doi.org/10.3390/ijms21072364
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author Pricci, Maria
Girardi, Bruna
Giorgio, Floriana
Losurdo, Giuseppe
Ierardi, Enzo
Di Leo, Alfredo
author_facet Pricci, Maria
Girardi, Bruna
Giorgio, Floriana
Losurdo, Giuseppe
Ierardi, Enzo
Di Leo, Alfredo
author_sort Pricci, Maria
collection PubMed
description Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, and anti-angiogenic purposes. We conducted a literature review to summarize studies investigating the relationship between curcumin and colorectal cancer (CRC). In vitro studies, performed on human colon cancer cell lines, showed that curcumin inhibited cellular growth through cycle arrest at the G2/M and G1 phases, as well as stimulated apoptosis by interacting with multiple molecular targets. In vivo studies have been performed in inflammatory and genetic CRC animal models with a chemopreventive effect. To improve curcumin bioavailability, it has been associated with small particles that increase its absorption when orally administered with excellent results on both inflammation and carcinogenesis. Curcumin has been used, moreover, as a component of dietetic formulations for CRC chemoprevention. These combinations showed in vitro and in vivo anticarcinogenetic properties in inflammation-related and genetic CRC. A synergic effect was suggested using an individual constituent dosage, which was lower than that experimentally used “in vivo” for single components. In conclusion, curcumin falls within the category of plant origin substances able to prevent CRC in animals. This property offers promising expectations in humans.
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spelling pubmed-71782002020-04-28 Curcumin and Colorectal Cancer: From Basic to Clinical Evidences Pricci, Maria Girardi, Bruna Giorgio, Floriana Losurdo, Giuseppe Ierardi, Enzo Di Leo, Alfredo Int J Mol Sci Review Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, and anti-angiogenic purposes. We conducted a literature review to summarize studies investigating the relationship between curcumin and colorectal cancer (CRC). In vitro studies, performed on human colon cancer cell lines, showed that curcumin inhibited cellular growth through cycle arrest at the G2/M and G1 phases, as well as stimulated apoptosis by interacting with multiple molecular targets. In vivo studies have been performed in inflammatory and genetic CRC animal models with a chemopreventive effect. To improve curcumin bioavailability, it has been associated with small particles that increase its absorption when orally administered with excellent results on both inflammation and carcinogenesis. Curcumin has been used, moreover, as a component of dietetic formulations for CRC chemoprevention. These combinations showed in vitro and in vivo anticarcinogenetic properties in inflammation-related and genetic CRC. A synergic effect was suggested using an individual constituent dosage, which was lower than that experimentally used “in vivo” for single components. In conclusion, curcumin falls within the category of plant origin substances able to prevent CRC in animals. This property offers promising expectations in humans. MDPI 2020-03-29 /pmc/articles/PMC7178200/ /pubmed/32235371 http://dx.doi.org/10.3390/ijms21072364 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pricci, Maria
Girardi, Bruna
Giorgio, Floriana
Losurdo, Giuseppe
Ierardi, Enzo
Di Leo, Alfredo
Curcumin and Colorectal Cancer: From Basic to Clinical Evidences
title Curcumin and Colorectal Cancer: From Basic to Clinical Evidences
title_full Curcumin and Colorectal Cancer: From Basic to Clinical Evidences
title_fullStr Curcumin and Colorectal Cancer: From Basic to Clinical Evidences
title_full_unstemmed Curcumin and Colorectal Cancer: From Basic to Clinical Evidences
title_short Curcumin and Colorectal Cancer: From Basic to Clinical Evidences
title_sort curcumin and colorectal cancer: from basic to clinical evidences
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178200/
https://www.ncbi.nlm.nih.gov/pubmed/32235371
http://dx.doi.org/10.3390/ijms21072364
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