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Computational Investigation on the p53–MDM2 Interaction Using the Potential of Mean Force Study
[Image: see text] Murine double minute 2 (MDM2) proteins are found to be overproduced by many human tumors in order to inhibit the functioning of p53 molecules, a tumor suppressor protein. Thus, reactivating p53 functioning in cancer cells by disrupting p53–MDM2 interactions may offer a significant...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178334/ https://www.ncbi.nlm.nih.gov/pubmed/32337406 http://dx.doi.org/10.1021/acsomega.9b03372 |