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The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study
BACKGROUND: Olfactory dysfunction is a prevalent problem with a significant impact on quality of life and increased mortality. Limited effective therapies exist. Platelet‐rich plasma (PRP) is an autologous biologic product with anti‐inflammatory and neuroprotective effects. This novel pilot study ev...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178450/ https://www.ncbi.nlm.nih.gov/pubmed/32337347 http://dx.doi.org/10.1002/lio2.357 |
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author | Yan, Carol H. Mundy, David C. Patel, Zara M. |
author_facet | Yan, Carol H. Mundy, David C. Patel, Zara M. |
author_sort | Yan, Carol H. |
collection | PubMed |
description | BACKGROUND: Olfactory dysfunction is a prevalent problem with a significant impact on quality of life and increased mortality. Limited effective therapies exist. Platelet‐rich plasma (PRP) is an autologous biologic product with anti‐inflammatory and neuroprotective effects. This novel pilot study evaluated the role of PRP on olfactory neuroregeneration in patients with hyposmia. METHODS: Seven patients who had olfactory loss greater than 6 months in duration, no evidence of sinonasal inflammatory disease, and no improvement with olfactory training and budesonide topical rinses were enrolled in this preliminary study. Patients received a single intranasal injection of PRP into the mucosa of the olfactory cleft. The Sniffin' Sticks olfactory test consisting of threshold, discrimination, and identification measurements (TDI) was administered at the beginning of the study and at 1 and 3 months. RESULTS: All patients reported a subjective improvement of their smell shortly after injection but then stabilized. At 3‐month post‐treatment, two patients with functional anosmia (TDI < 16) did not improve significantly. Five patients with hyposmia (TDI > 16 but <30) showed an improvement with 60% achieving normosmia (TDI > 30) at 3‐month follow‐up. On average, patients with baseline TDI > 16 improved by 5.85 points with the most significant improvement in the threshold subcomponent. There were no adverse outcomes from intranasal PRP injections. CONCLUSION: PRP appears safe for use in the treatment of olfactory loss, and preliminary data suggest possible efficacy, especially for those with moderate yet persistent loss. Further studies will help determine optimal frequency and duration of use. LEVEL OF EVIDENCE: 2B: |
format | Online Article Text |
id | pubmed-7178450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71784502020-04-24 The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study Yan, Carol H. Mundy, David C. Patel, Zara M. Laryngoscope Investig Otolaryngol Allergy, Rhinology, and Immunology BACKGROUND: Olfactory dysfunction is a prevalent problem with a significant impact on quality of life and increased mortality. Limited effective therapies exist. Platelet‐rich plasma (PRP) is an autologous biologic product with anti‐inflammatory and neuroprotective effects. This novel pilot study evaluated the role of PRP on olfactory neuroregeneration in patients with hyposmia. METHODS: Seven patients who had olfactory loss greater than 6 months in duration, no evidence of sinonasal inflammatory disease, and no improvement with olfactory training and budesonide topical rinses were enrolled in this preliminary study. Patients received a single intranasal injection of PRP into the mucosa of the olfactory cleft. The Sniffin' Sticks olfactory test consisting of threshold, discrimination, and identification measurements (TDI) was administered at the beginning of the study and at 1 and 3 months. RESULTS: All patients reported a subjective improvement of their smell shortly after injection but then stabilized. At 3‐month post‐treatment, two patients with functional anosmia (TDI < 16) did not improve significantly. Five patients with hyposmia (TDI > 16 but <30) showed an improvement with 60% achieving normosmia (TDI > 30) at 3‐month follow‐up. On average, patients with baseline TDI > 16 improved by 5.85 points with the most significant improvement in the threshold subcomponent. There were no adverse outcomes from intranasal PRP injections. CONCLUSION: PRP appears safe for use in the treatment of olfactory loss, and preliminary data suggest possible efficacy, especially for those with moderate yet persistent loss. Further studies will help determine optimal frequency and duration of use. LEVEL OF EVIDENCE: 2B: John Wiley & Sons, Inc. 2020-02-21 /pmc/articles/PMC7178450/ /pubmed/32337347 http://dx.doi.org/10.1002/lio2.357 Text en © 2020 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Allergy, Rhinology, and Immunology Yan, Carol H. Mundy, David C. Patel, Zara M. The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study |
title | The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study |
title_full | The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study |
title_fullStr | The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study |
title_full_unstemmed | The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study |
title_short | The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study |
title_sort | use of platelet‐rich plasma in treatment of olfactory dysfunction: a pilot study |
topic | Allergy, Rhinology, and Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178450/ https://www.ncbi.nlm.nih.gov/pubmed/32337347 http://dx.doi.org/10.1002/lio2.357 |
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