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Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia

This study explores several speech parameters related to mild cognitive impairment, as well as those that might be flagging the presence of an underlying neurodegenerative process. Speech is an excellent biomarker because it is not invasive and, what is more, its analysis is rapid and economical. Ou...

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Detalles Bibliográficos
Autores principales: Meilán, Juan J. G., Martínez-Sánchez, Francisco, Martínez-Nicolás, Israel, Llorente, Thide E., Carro, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178534/
https://www.ncbi.nlm.nih.gov/pubmed/32351632
http://dx.doi.org/10.1155/2020/4683573
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author Meilán, Juan J. G.
Martínez-Sánchez, Francisco
Martínez-Nicolás, Israel
Llorente, Thide E.
Carro, Juan
author_facet Meilán, Juan J. G.
Martínez-Sánchez, Francisco
Martínez-Nicolás, Israel
Llorente, Thide E.
Carro, Juan
author_sort Meilán, Juan J. G.
collection PubMed
description This study explores several speech parameters related to mild cognitive impairment, as well as those that might be flagging the presence of an underlying neurodegenerative process. Speech is an excellent biomarker because it is not invasive and, what is more, its analysis is rapid and economical. Our aim has been to ascertain whether the typical speech patterns of people with Alzheimer's disease are also present during the disorder's preclinical stages. To do so, we shall be using a task that involves reading out aloud. This is followed by an analysis of the recordings, looking for the possible parameters differentiating between those older people with MCI and a high probability of developing dementia and those with MCI that will not do so. We found that the disease's most differentiating parameters prior to its onset involve changes in speech duration and an alteration in rhythm rate and intensity. These parameters seem to be related to the first difficulties in lexical access among older people with AD.
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spelling pubmed-71785342020-04-29 Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia Meilán, Juan J. G. Martínez-Sánchez, Francisco Martínez-Nicolás, Israel Llorente, Thide E. Carro, Juan Behav Neurol Research Article This study explores several speech parameters related to mild cognitive impairment, as well as those that might be flagging the presence of an underlying neurodegenerative process. Speech is an excellent biomarker because it is not invasive and, what is more, its analysis is rapid and economical. Our aim has been to ascertain whether the typical speech patterns of people with Alzheimer's disease are also present during the disorder's preclinical stages. To do so, we shall be using a task that involves reading out aloud. This is followed by an analysis of the recordings, looking for the possible parameters differentiating between those older people with MCI and a high probability of developing dementia and those with MCI that will not do so. We found that the disease's most differentiating parameters prior to its onset involve changes in speech duration and an alteration in rhythm rate and intensity. These parameters seem to be related to the first difficulties in lexical access among older people with AD. Hindawi 2020-04-14 /pmc/articles/PMC7178534/ /pubmed/32351632 http://dx.doi.org/10.1155/2020/4683573 Text en Copyright © 2020 Juan J. G. Meilán et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Meilán, Juan J. G.
Martínez-Sánchez, Francisco
Martínez-Nicolás, Israel
Llorente, Thide E.
Carro, Juan
Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia
title Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia
title_full Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia
title_fullStr Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia
title_full_unstemmed Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia
title_short Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia
title_sort changes in the rhythm of speech difference between people with nondegenerative mild cognitive impairment and with preclinical dementia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178534/
https://www.ncbi.nlm.nih.gov/pubmed/32351632
http://dx.doi.org/10.1155/2020/4683573
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