Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis

Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of Aesculus, which enriched its chemical compos...

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Detalles Bibliográficos
Autores principales: Zhang, Nan, Liu, Di, Wei, Shuxiang, Cao, Shijie, Feng, Xinchi, Wang, Kai, Ding, Liqin, Qiu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178748/
https://www.ncbi.nlm.nih.gov/pubmed/32337510
http://dx.doi.org/10.1186/s13065-020-00685-3
Descripción
Sumario:Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of Aesculus, which enriched its chemical composition. Structure elucidations were performed via extensive NMR and HRESIMS data together with comparison with literature data. Thereafter, the isolated compounds were assayed for their neuroprotective activities against CoCl(2)-induced cytotoxicity in PC12 cells and compound 3 exhibited moderate activity. [Image: see text]

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