Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis

Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of Aesculus, which enriched its chemical compos...

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Autores principales: Zhang, Nan, Liu, Di, Wei, Shuxiang, Cao, Shijie, Feng, Xinchi, Wang, Kai, Ding, Liqin, Qiu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178748/
https://www.ncbi.nlm.nih.gov/pubmed/32337510
http://dx.doi.org/10.1186/s13065-020-00685-3
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author Zhang, Nan
Liu, Di
Wei, Shuxiang
Cao, Shijie
Feng, Xinchi
Wang, Kai
Ding, Liqin
Qiu, Feng
author_facet Zhang, Nan
Liu, Di
Wei, Shuxiang
Cao, Shijie
Feng, Xinchi
Wang, Kai
Ding, Liqin
Qiu, Feng
author_sort Zhang, Nan
collection PubMed
description Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of Aesculus, which enriched its chemical composition. Structure elucidations were performed via extensive NMR and HRESIMS data together with comparison with literature data. Thereafter, the isolated compounds were assayed for their neuroprotective activities against CoCl(2)-induced cytotoxicity in PC12 cells and compound 3 exhibited moderate activity. [Image: see text]
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spelling pubmed-71787482020-04-26 Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis Zhang, Nan Liu, Di Wei, Shuxiang Cao, Shijie Feng, Xinchi Wang, Kai Ding, Liqin Qiu, Feng BMC Chem Research Article Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of Aesculus, which enriched its chemical composition. Structure elucidations were performed via extensive NMR and HRESIMS data together with comparison with literature data. Thereafter, the isolated compounds were assayed for their neuroprotective activities against CoCl(2)-induced cytotoxicity in PC12 cells and compound 3 exhibited moderate activity. [Image: see text] Springer International Publishing 2020-04-22 /pmc/articles/PMC7178748/ /pubmed/32337510 http://dx.doi.org/10.1186/s13065-020-00685-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zhang, Nan
Liu, Di
Wei, Shuxiang
Cao, Shijie
Feng, Xinchi
Wang, Kai
Ding, Liqin
Qiu, Feng
Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis
title Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis
title_full Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis
title_fullStr Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis
title_full_unstemmed Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis
title_short Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis
title_sort phenylethanol glycosides from the seeds of aesculus chinensis var. chekiangensis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178748/
https://www.ncbi.nlm.nih.gov/pubmed/32337510
http://dx.doi.org/10.1186/s13065-020-00685-3
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