Effect of Protein and Mechanical Strain on the Corrosion Resistance and Cytotoxicity of the Orthodontic Composite Arch Wire

[Image: see text] In this study, the effects of the exposure to different types of salivary proteins (fibrinogen, IgG, and mucin) and application of an in vitro bending strain on the laser welding orthodontic composite arch wire (CAW) were investigated, and the resultant corrosion behavior and cytotoxicity were studied in vitro. The purpose was to determine the mechanisms by which protein exposure and bending loads contribute to the corrosion of the CAW either alone or in combination by mimicking the clinical application. The results showed that the application of a mechanical strain significantly decreased the corrosion resistance of the CAW and increased the release of toxic corrosion products. The addition of the proteins inhibited the corrosion of the CAW, but the mechanical loads counteracted this effect. Mucin enhanced the corrosion resistance of the CAW. The effects of the proteins or strain, either alone or in combination, should be considered in the application of medical materials of heterogenetic alloys.