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Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient

Hepatitis C virus (HCV) infection is known to affect long-term patient survivals. Elbasvir/grazoprevir (EBR/GZR) has shown a high cure rate in hemodialysis patients with HCV infection. However, the combination is rarely used in peritoneal dialysis patients. Herein, we report a case of successful tre...

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Autores principales: Chen, Jin, Li, Yi, Li, Guisen, Lei, Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178844/
https://www.ncbi.nlm.nih.gov/pubmed/32301365
http://dx.doi.org/10.1080/0886022X.2020.1753073
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author Chen, Jin
Li, Yi
Li, Guisen
Lei, Pu
author_facet Chen, Jin
Li, Yi
Li, Guisen
Lei, Pu
author_sort Chen, Jin
collection PubMed
description Hepatitis C virus (HCV) infection is known to affect long-term patient survivals. Elbasvir/grazoprevir (EBR/GZR) has shown a high cure rate in hemodialysis patients with HCV infection. However, the combination is rarely used in peritoneal dialysis patients. Herein, we report a case of successful treatment with EBR/GZR in a peritoneal dialysis patient with HCV genotype 1 b infection. A 54-year-old woman on peritoneal dialysis(PD)with HCV genotype 1 b infection had been received EBR (100 mg) and GZR (50 mg) once daily for 12 weeks. Hepatitis C virus RNA was undetectable 4 weeks after the treatment. She achieved a sustained virological response at 12 weeks after the end of treatment. Only fatigue was reported as side effect during the treatment. Thus, elbasvir/grazoprevir was effective and safe in this PD patient with HCV genotype 1 b infection.
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spelling pubmed-71788442020-05-01 Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient Chen, Jin Li, Yi Li, Guisen Lei, Pu Ren Fail Brief Report Hepatitis C virus (HCV) infection is known to affect long-term patient survivals. Elbasvir/grazoprevir (EBR/GZR) has shown a high cure rate in hemodialysis patients with HCV infection. However, the combination is rarely used in peritoneal dialysis patients. Herein, we report a case of successful treatment with EBR/GZR in a peritoneal dialysis patient with HCV genotype 1 b infection. A 54-year-old woman on peritoneal dialysis(PD)with HCV genotype 1 b infection had been received EBR (100 mg) and GZR (50 mg) once daily for 12 weeks. Hepatitis C virus RNA was undetectable 4 weeks after the treatment. She achieved a sustained virological response at 12 weeks after the end of treatment. Only fatigue was reported as side effect during the treatment. Thus, elbasvir/grazoprevir was effective and safe in this PD patient with HCV genotype 1 b infection. Taylor & Francis 2020-04-17 /pmc/articles/PMC7178844/ /pubmed/32301365 http://dx.doi.org/10.1080/0886022X.2020.1753073 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Chen, Jin
Li, Yi
Li, Guisen
Lei, Pu
Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient
title Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient
title_full Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient
title_fullStr Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient
title_full_unstemmed Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient
title_short Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient
title_sort elbasvir/grazoprevir treatment in an hcv-infected peritoneal dialysis patient
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178844/
https://www.ncbi.nlm.nih.gov/pubmed/32301365
http://dx.doi.org/10.1080/0886022X.2020.1753073
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