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Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient
Hepatitis C virus (HCV) infection is known to affect long-term patient survivals. Elbasvir/grazoprevir (EBR/GZR) has shown a high cure rate in hemodialysis patients with HCV infection. However, the combination is rarely used in peritoneal dialysis patients. Herein, we report a case of successful tre...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178844/ https://www.ncbi.nlm.nih.gov/pubmed/32301365 http://dx.doi.org/10.1080/0886022X.2020.1753073 |
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author | Chen, Jin Li, Yi Li, Guisen Lei, Pu |
author_facet | Chen, Jin Li, Yi Li, Guisen Lei, Pu |
author_sort | Chen, Jin |
collection | PubMed |
description | Hepatitis C virus (HCV) infection is known to affect long-term patient survivals. Elbasvir/grazoprevir (EBR/GZR) has shown a high cure rate in hemodialysis patients with HCV infection. However, the combination is rarely used in peritoneal dialysis patients. Herein, we report a case of successful treatment with EBR/GZR in a peritoneal dialysis patient with HCV genotype 1 b infection. A 54-year-old woman on peritoneal dialysis(PD)with HCV genotype 1 b infection had been received EBR (100 mg) and GZR (50 mg) once daily for 12 weeks. Hepatitis C virus RNA was undetectable 4 weeks after the treatment. She achieved a sustained virological response at 12 weeks after the end of treatment. Only fatigue was reported as side effect during the treatment. Thus, elbasvir/grazoprevir was effective and safe in this PD patient with HCV genotype 1 b infection. |
format | Online Article Text |
id | pubmed-7178844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-71788442020-05-01 Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient Chen, Jin Li, Yi Li, Guisen Lei, Pu Ren Fail Brief Report Hepatitis C virus (HCV) infection is known to affect long-term patient survivals. Elbasvir/grazoprevir (EBR/GZR) has shown a high cure rate in hemodialysis patients with HCV infection. However, the combination is rarely used in peritoneal dialysis patients. Herein, we report a case of successful treatment with EBR/GZR in a peritoneal dialysis patient with HCV genotype 1 b infection. A 54-year-old woman on peritoneal dialysis(PD)with HCV genotype 1 b infection had been received EBR (100 mg) and GZR (50 mg) once daily for 12 weeks. Hepatitis C virus RNA was undetectable 4 weeks after the treatment. She achieved a sustained virological response at 12 weeks after the end of treatment. Only fatigue was reported as side effect during the treatment. Thus, elbasvir/grazoprevir was effective and safe in this PD patient with HCV genotype 1 b infection. Taylor & Francis 2020-04-17 /pmc/articles/PMC7178844/ /pubmed/32301365 http://dx.doi.org/10.1080/0886022X.2020.1753073 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Chen, Jin Li, Yi Li, Guisen Lei, Pu Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient |
title | Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient |
title_full | Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient |
title_fullStr | Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient |
title_full_unstemmed | Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient |
title_short | Elbasvir/grazoprevir treatment in an HCV-infected peritoneal dialysis patient |
title_sort | elbasvir/grazoprevir treatment in an hcv-infected peritoneal dialysis patient |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178844/ https://www.ncbi.nlm.nih.gov/pubmed/32301365 http://dx.doi.org/10.1080/0886022X.2020.1753073 |
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