Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters

We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B...

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Autores principales: Won, Eun Jeong, Joo, Min Young, Lee, Dain, Kim, Mi-Na, Park, Yeon-Joon, Kim, Soo Hyun, Shin, Myung Geun, Shin, Jong Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178884/
https://www.ncbi.nlm.nih.gov/pubmed/32363043
http://dx.doi.org/10.1080/12298093.2020.1744955
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author Won, Eun Jeong
Joo, Min Young
Lee, Dain
Kim, Mi-Na
Park, Yeon-Joon
Kim, Soo Hyun
Shin, Myung Geun
Shin, Jong Hee
author_facet Won, Eun Jeong
Joo, Min Young
Lee, Dain
Kim, Mi-Na
Park, Yeon-Joon
Kim, Soo Hyun
Shin, Myung Geun
Shin, Jong Hee
author_sort Won, Eun Jeong
collection PubMed
description We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions: Nine isolates harbored one to five mutations in cyp51A with high polymorphism, and 11 isolates exhibited the same Q42L mutation in cyp51B. Overall, a low azole resistance rate and high frequency of cyp51A/cyp51B amino acid substitutions were observed in the azole-susceptible A. fumigatus isolates in Korea.
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spelling pubmed-71788842020-05-01 Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters Won, Eun Jeong Joo, Min Young Lee, Dain Kim, Mi-Na Park, Yeon-Joon Kim, Soo Hyun Shin, Myung Geun Shin, Jong Hee Mycobiology Research Note We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions: Nine isolates harbored one to five mutations in cyp51A with high polymorphism, and 11 isolates exhibited the same Q42L mutation in cyp51B. Overall, a low azole resistance rate and high frequency of cyp51A/cyp51B amino acid substitutions were observed in the azole-susceptible A. fumigatus isolates in Korea. Taylor & Francis 2020-04-10 /pmc/articles/PMC7178884/ /pubmed/32363043 http://dx.doi.org/10.1080/12298093.2020.1744955 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the Korean Society of Mycology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Note
Won, Eun Jeong
Joo, Min Young
Lee, Dain
Kim, Mi-Na
Park, Yeon-Joon
Kim, Soo Hyun
Shin, Myung Geun
Shin, Jong Hee
Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters
title Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters
title_full Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters
title_fullStr Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters
title_full_unstemmed Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters
title_short Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters
title_sort antifungal susceptibility tests and the cyp51 mutant strains among clinical aspergillus fumigatus isolates from korean multicenters
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178884/
https://www.ncbi.nlm.nih.gov/pubmed/32363043
http://dx.doi.org/10.1080/12298093.2020.1744955
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