Recent advances in human iPSC-derived models of the blood–brain barrier

The blood–brain barrier (BBB) is a critical component of the central nervous system that protects neurons and other cells of the brain parenchyma from potentially harmful substances found in peripheral circulation. Gaining a thorough understanding of the development and function of the human BBB has...

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Detalles Bibliográficos
Autores principales: Workman, Michael J., Svendsen, Clive N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178976/
https://www.ncbi.nlm.nih.gov/pubmed/32321511
http://dx.doi.org/10.1186/s12987-020-00191-7
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author Workman, Michael J.
Svendsen, Clive N.
author_facet Workman, Michael J.
Svendsen, Clive N.
author_sort Workman, Michael J.
collection PubMed
description The blood–brain barrier (BBB) is a critical component of the central nervous system that protects neurons and other cells of the brain parenchyma from potentially harmful substances found in peripheral circulation. Gaining a thorough understanding of the development and function of the human BBB has been hindered by a lack of relevant models given significant species differences and limited access to in vivo tissue. However, advances in induced pluripotent stem cell (iPSC) and organ-chip technologies now allow us to improve our knowledge of the human BBB in both health and disease. This review focuses on the recent progress in modeling the BBB in vitro using human iPSCs.
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spelling pubmed-71789762020-04-26 Recent advances in human iPSC-derived models of the blood–brain barrier Workman, Michael J. Svendsen, Clive N. Fluids Barriers CNS Review The blood–brain barrier (BBB) is a critical component of the central nervous system that protects neurons and other cells of the brain parenchyma from potentially harmful substances found in peripheral circulation. Gaining a thorough understanding of the development and function of the human BBB has been hindered by a lack of relevant models given significant species differences and limited access to in vivo tissue. However, advances in induced pluripotent stem cell (iPSC) and organ-chip technologies now allow us to improve our knowledge of the human BBB in both health and disease. This review focuses on the recent progress in modeling the BBB in vitro using human iPSCs. BioMed Central 2020-04-22 /pmc/articles/PMC7178976/ /pubmed/32321511 http://dx.doi.org/10.1186/s12987-020-00191-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Workman, Michael J.
Svendsen, Clive N.
Recent advances in human iPSC-derived models of the blood–brain barrier
title Recent advances in human iPSC-derived models of the blood–brain barrier
title_full Recent advances in human iPSC-derived models of the blood–brain barrier
title_fullStr Recent advances in human iPSC-derived models of the blood–brain barrier
title_full_unstemmed Recent advances in human iPSC-derived models of the blood–brain barrier
title_short Recent advances in human iPSC-derived models of the blood–brain barrier
title_sort recent advances in human ipsc-derived models of the blood–brain barrier
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178976/
https://www.ncbi.nlm.nih.gov/pubmed/32321511
http://dx.doi.org/10.1186/s12987-020-00191-7
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