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Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro
The following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer f...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179029/ https://www.ncbi.nlm.nih.gov/pubmed/32283855 http://dx.doi.org/10.3390/ma13071771 |
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author | Maciejewski, Bartosz Arumughan, Vishnu Larsson, Anette Sznitowska, Małgorzata |
author_facet | Maciejewski, Bartosz Arumughan, Vishnu Larsson, Anette Sznitowska, Małgorzata |
author_sort | Maciejewski, Bartosz |
collection | PubMed |
description | The following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer films was performed. The results suggest that the critical feature behind formation of the acid-resistant films is a spinodal decomposition in the film-forming mixture. In the obtained films, upon submersion in an acidic medium, gelatin swells and dissolves, exposing a CAP-based acid-insoluble skeleton, partially coated by a residue of other ingredients. The dissolution-hindering effect appears to be stronger when iota-carrageenan is added to the film-forming mixture. The drug release study performed in enhancer cells confirmed that diclofenac sodium is not released in the acidic medium, however, at pH 6.8 the drug release occurs. The capsules prepared with a simple lab-scale process appear to be resistant to disintegration of the shell structure in acid, although imperfections of the sealing have been noticed. |
format | Online Article Text |
id | pubmed-7179029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71790292020-04-28 Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro Maciejewski, Bartosz Arumughan, Vishnu Larsson, Anette Sznitowska, Małgorzata Materials (Basel) Article The following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer films was performed. The results suggest that the critical feature behind formation of the acid-resistant films is a spinodal decomposition in the film-forming mixture. In the obtained films, upon submersion in an acidic medium, gelatin swells and dissolves, exposing a CAP-based acid-insoluble skeleton, partially coated by a residue of other ingredients. The dissolution-hindering effect appears to be stronger when iota-carrageenan is added to the film-forming mixture. The drug release study performed in enhancer cells confirmed that diclofenac sodium is not released in the acidic medium, however, at pH 6.8 the drug release occurs. The capsules prepared with a simple lab-scale process appear to be resistant to disintegration of the shell structure in acid, although imperfections of the sealing have been noticed. MDPI 2020-04-09 /pmc/articles/PMC7179029/ /pubmed/32283855 http://dx.doi.org/10.3390/ma13071771 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Maciejewski, Bartosz Arumughan, Vishnu Larsson, Anette Sznitowska, Małgorzata Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
title | Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
title_full | Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
title_fullStr | Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
title_full_unstemmed | Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
title_short | Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
title_sort | prototype gastro-resistant soft gelatin films and capsules—imaging and performance in vitro |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179029/ https://www.ncbi.nlm.nih.gov/pubmed/32283855 http://dx.doi.org/10.3390/ma13071771 |
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