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Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro

The following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer f...

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Autores principales: Maciejewski, Bartosz, Arumughan, Vishnu, Larsson, Anette, Sznitowska, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179029/
https://www.ncbi.nlm.nih.gov/pubmed/32283855
http://dx.doi.org/10.3390/ma13071771
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author Maciejewski, Bartosz
Arumughan, Vishnu
Larsson, Anette
Sznitowska, Małgorzata
author_facet Maciejewski, Bartosz
Arumughan, Vishnu
Larsson, Anette
Sznitowska, Małgorzata
author_sort Maciejewski, Bartosz
collection PubMed
description The following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer films was performed. The results suggest that the critical feature behind formation of the acid-resistant films is a spinodal decomposition in the film-forming mixture. In the obtained films, upon submersion in an acidic medium, gelatin swells and dissolves, exposing a CAP-based acid-insoluble skeleton, partially coated by a residue of other ingredients. The dissolution-hindering effect appears to be stronger when iota-carrageenan is added to the film-forming mixture. The drug release study performed in enhancer cells confirmed that diclofenac sodium is not released in the acidic medium, however, at pH 6.8 the drug release occurs. The capsules prepared with a simple lab-scale process appear to be resistant to disintegration of the shell structure in acid, although imperfections of the sealing have been noticed.
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spelling pubmed-71790292020-04-28 Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro Maciejewski, Bartosz Arumughan, Vishnu Larsson, Anette Sznitowska, Małgorzata Materials (Basel) Article The following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer films was performed. The results suggest that the critical feature behind formation of the acid-resistant films is a spinodal decomposition in the film-forming mixture. In the obtained films, upon submersion in an acidic medium, gelatin swells and dissolves, exposing a CAP-based acid-insoluble skeleton, partially coated by a residue of other ingredients. The dissolution-hindering effect appears to be stronger when iota-carrageenan is added to the film-forming mixture. The drug release study performed in enhancer cells confirmed that diclofenac sodium is not released in the acidic medium, however, at pH 6.8 the drug release occurs. The capsules prepared with a simple lab-scale process appear to be resistant to disintegration of the shell structure in acid, although imperfections of the sealing have been noticed. MDPI 2020-04-09 /pmc/articles/PMC7179029/ /pubmed/32283855 http://dx.doi.org/10.3390/ma13071771 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maciejewski, Bartosz
Arumughan, Vishnu
Larsson, Anette
Sznitowska, Małgorzata
Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro
title Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro
title_full Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro
title_fullStr Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro
title_full_unstemmed Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro
title_short Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro
title_sort prototype gastro-resistant soft gelatin films and capsules—imaging and performance in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179029/
https://www.ncbi.nlm.nih.gov/pubmed/32283855
http://dx.doi.org/10.3390/ma13071771
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