Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters

Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions...

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Detalles Bibliográficos
Autores principales: Mkhonazi, Blessing D., Shandu, Malibongwe, Tshinavhe, Ronewa, Simelane, Sandile B., Moshapo, Paseka T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179140/
https://www.ncbi.nlm.nih.gov/pubmed/32110915
http://dx.doi.org/10.3390/molecules25051040
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author Mkhonazi, Blessing D.
Shandu, Malibongwe
Tshinavhe, Ronewa
Simelane, Sandile B.
Moshapo, Paseka T.
author_facet Mkhonazi, Blessing D.
Shandu, Malibongwe
Tshinavhe, Ronewa
Simelane, Sandile B.
Moshapo, Paseka T.
author_sort Mkhonazi, Blessing D.
collection PubMed
description Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%.
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spelling pubmed-71791402020-04-28 Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters Mkhonazi, Blessing D. Shandu, Malibongwe Tshinavhe, Ronewa Simelane, Sandile B. Moshapo, Paseka T. Molecules Article Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%. MDPI 2020-02-26 /pmc/articles/PMC7179140/ /pubmed/32110915 http://dx.doi.org/10.3390/molecules25051040 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mkhonazi, Blessing D.
Shandu, Malibongwe
Tshinavhe, Ronewa
Simelane, Sandile B.
Moshapo, Paseka T.
Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters
title Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters
title_full Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters
title_fullStr Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters
title_full_unstemmed Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters
title_short Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters
title_sort solvent-free iron(iii) chloride-catalyzed direct amidation of esters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179140/
https://www.ncbi.nlm.nih.gov/pubmed/32110915
http://dx.doi.org/10.3390/molecules25051040
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AT shandumalibongwe solventfreeironiiichloridecatalyzeddirectamidationofesters
AT tshinavheronewa solventfreeironiiichloridecatalyzeddirectamidationofesters
AT simelanesandileb solventfreeironiiichloridecatalyzeddirectamidationofesters
AT moshapopasekat solventfreeironiiichloridecatalyzeddirectamidationofesters

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