Direct Dehydrative Glycosylation Catalyzed by Diphenylammonium Triflate

Methods for direct dehydrative glycosylations of carbohydrate hemiacetals catalyzed by diphenylammonium triflate under microwave irradiation are described. Both armed and disarmed glycosyl-C1-hemiacetal donors were efficiently glycosylated in moderate to excellent yields without the need for any dry...

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Detalles Bibliográficos
Autores principales: Hsu, Mei-Yuan, Lam, Sarah, Wu, Chia-Hui, Lin, Mei-Huei, Lin, Su-Ching, Wang, Cheng-Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179217/
https://www.ncbi.nlm.nih.gov/pubmed/32131396
http://dx.doi.org/10.3390/molecules25051103
Descripción
Sumario:Methods for direct dehydrative glycosylations of carbohydrate hemiacetals catalyzed by diphenylammonium triflate under microwave irradiation are described. Both armed and disarmed glycosyl-C1-hemiacetal donors were efficiently glycosylated in moderate to excellent yields without the need for any drying agents and stoichiometric additives. This method has been successfully applied to a solid-phase glycosylation.

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