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Design, Synthesis, and Biological Evaluation of Aromatic Amide-Substituted Benzimidazole-Derived Chalcones. The Effect of Upregulating TP53 Protein Expression

A series of benzimidazole-derived chalcones containing aromatic amide substituent were designed and synthesized. All of the chalcone compounds were tested for their in vitro antitumor activity against human cancer cell lines (HCT116, HepG2, A549, and CRL-5908). The antiproliferative activity of comp...

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Detalles Bibliográficos
Autores principales:	Wu, Lintao, Yang, Yuting, Wang, Zhijun, Wu, Xi, Su, Feng, Li, Mengyao, Jing, Xiaobi, Han, Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179225/ https://www.ncbi.nlm.nih.gov/pubmed/32150865 http://dx.doi.org/10.3390/molecules25051162

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