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A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment

The development of selective tumor targeting agents to deliver multiple units of chemotherapy drugs to cancer tissue would improve treatment efficacy and greatly advance progress in cancer therapy. Here we report a new drug delivery system based on a tetrabranched peptide known as NT4, which is a pr...

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Autores principales: Brunetti, Jlenia, Piantini, Sara, Fragai, Marco, Scali, Silvia, Cipriani, Giulia, Depau, Lorenzo, Pini, Alessandro, Falciani, Chiara, Menichetti, Stefano, Bracci, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179244/
https://www.ncbi.nlm.nih.gov/pubmed/32121130
http://dx.doi.org/10.3390/molecules25051088
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author Brunetti, Jlenia
Piantini, Sara
Fragai, Marco
Scali, Silvia
Cipriani, Giulia
Depau, Lorenzo
Pini, Alessandro
Falciani, Chiara
Menichetti, Stefano
Bracci, Luisa
author_facet Brunetti, Jlenia
Piantini, Sara
Fragai, Marco
Scali, Silvia
Cipriani, Giulia
Depau, Lorenzo
Pini, Alessandro
Falciani, Chiara
Menichetti, Stefano
Bracci, Luisa
author_sort Brunetti, Jlenia
collection PubMed
description The development of selective tumor targeting agents to deliver multiple units of chemotherapy drugs to cancer tissue would improve treatment efficacy and greatly advance progress in cancer therapy. Here we report a new drug delivery system based on a tetrabranched peptide known as NT4, which is a promising cancer theranostic by virtue of its high cancer selectivity. We developed NT4 directly conjugated with one, two, or three units of paclitaxel and an NT4-based nanosystem, using NIR-emitting quantum dots, loaded with the NT4 tumor-targeting agent and conjugated with paclitaxel, to obtain a NT4-QD-PTX nanodevice designed to simultaneously detect and kill tumor cells. The selective binding and in vitro cytotoxicity of NT4-QD-PTX were higher than for unlabeled QD-PTX when tested on the human colon adenocarcinoma cell line HT-29. NT4-QD-PTX tumor-targeted nanoparticles can be considered promising for early tumor detection and for the development of effective treatments combining simultaneous therapy and diagnosis.
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spelling pubmed-71792442020-04-28 A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment Brunetti, Jlenia Piantini, Sara Fragai, Marco Scali, Silvia Cipriani, Giulia Depau, Lorenzo Pini, Alessandro Falciani, Chiara Menichetti, Stefano Bracci, Luisa Molecules Article The development of selective tumor targeting agents to deliver multiple units of chemotherapy drugs to cancer tissue would improve treatment efficacy and greatly advance progress in cancer therapy. Here we report a new drug delivery system based on a tetrabranched peptide known as NT4, which is a promising cancer theranostic by virtue of its high cancer selectivity. We developed NT4 directly conjugated with one, two, or three units of paclitaxel and an NT4-based nanosystem, using NIR-emitting quantum dots, loaded with the NT4 tumor-targeting agent and conjugated with paclitaxel, to obtain a NT4-QD-PTX nanodevice designed to simultaneously detect and kill tumor cells. The selective binding and in vitro cytotoxicity of NT4-QD-PTX were higher than for unlabeled QD-PTX when tested on the human colon adenocarcinoma cell line HT-29. NT4-QD-PTX tumor-targeted nanoparticles can be considered promising for early tumor detection and for the development of effective treatments combining simultaneous therapy and diagnosis. MDPI 2020-02-28 /pmc/articles/PMC7179244/ /pubmed/32121130 http://dx.doi.org/10.3390/molecules25051088 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brunetti, Jlenia
Piantini, Sara
Fragai, Marco
Scali, Silvia
Cipriani, Giulia
Depau, Lorenzo
Pini, Alessandro
Falciani, Chiara
Menichetti, Stefano
Bracci, Luisa
A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment
title A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment
title_full A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment
title_fullStr A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment
title_full_unstemmed A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment
title_short A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment
title_sort new nt4 peptide-based drug delivery system for cancer treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179244/
https://www.ncbi.nlm.nih.gov/pubmed/32121130
http://dx.doi.org/10.3390/molecules25051088
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