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Effects of erythropoietin on bile duct ligation-induced neuro-inflammation in male rats

Hepatic encephalopathy (HE) is a brain disorder as a result of liver failure. Previous studies have indicated that erythropoietin (EPO) has neuroprotective effects in different neurological diseases. This study addressed the therapeutic effect of a four-week treatment with EPO on neuronal damages in...

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Autores principales: Golshani, Moazameh, Basiri, Mohsen, Shabani, Mohammad, Aghaei, Iraj, Asadi-Shekaari, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIMS Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179341/
https://www.ncbi.nlm.nih.gov/pubmed/32341967
http://dx.doi.org/10.3934/Neuroscience.2019.2.43
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author Golshani, Moazameh
Basiri, Mohsen
Shabani, Mohammad
Aghaei, Iraj
Asadi-Shekaari, Majid
author_facet Golshani, Moazameh
Basiri, Mohsen
Shabani, Mohammad
Aghaei, Iraj
Asadi-Shekaari, Majid
author_sort Golshani, Moazameh
collection PubMed
description Hepatic encephalopathy (HE) is a brain disorder as a result of liver failure. Previous studies have indicated that erythropoietin (EPO) has neuroprotective effects in different neurological diseases. This study addressed the therapeutic effect of a four-week treatment with EPO on neuronal damages in bile duct-ligated rats. Forty male Wistar rats (250–280 g) were used in the present study. The animals were randomly divided into four groups consisting of 10 animals each, including sham, sham + EPO, bile duct ligation (BDL), and BDL + EPO. EPO was intraperitoneally administered every other day (5,000 U/Kg) in the last four weeks after BDL. Biochemical and histological studies were performed to evaluate neurodegeneration. The results revealed that BDL increases the level of hepatic enzymes and total bilirubin. Furthermore, neurodegeneration was significantly increased in the BDL group compared to sham groups. EPO preserved hepatic enzymes and total bilirubin in the treated group. In addition, EPO significantly decreased the neurodegeneration in BDL + EPO compared to the BDL group. Results of this study showed that EPO has neuroprotective effects in the rat model of HE, possibly due to its anti-inflammatory and anti-oxidant properties. Complementary studies are required to clarify the exact mechanisms.
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spelling pubmed-71793412020-04-27 Effects of erythropoietin on bile duct ligation-induced neuro-inflammation in male rats Golshani, Moazameh Basiri, Mohsen Shabani, Mohammad Aghaei, Iraj Asadi-Shekaari, Majid AIMS Neurosci Research Article Hepatic encephalopathy (HE) is a brain disorder as a result of liver failure. Previous studies have indicated that erythropoietin (EPO) has neuroprotective effects in different neurological diseases. This study addressed the therapeutic effect of a four-week treatment with EPO on neuronal damages in bile duct-ligated rats. Forty male Wistar rats (250–280 g) were used in the present study. The animals were randomly divided into four groups consisting of 10 animals each, including sham, sham + EPO, bile duct ligation (BDL), and BDL + EPO. EPO was intraperitoneally administered every other day (5,000 U/Kg) in the last four weeks after BDL. Biochemical and histological studies were performed to evaluate neurodegeneration. The results revealed that BDL increases the level of hepatic enzymes and total bilirubin. Furthermore, neurodegeneration was significantly increased in the BDL group compared to sham groups. EPO preserved hepatic enzymes and total bilirubin in the treated group. In addition, EPO significantly decreased the neurodegeneration in BDL + EPO compared to the BDL group. Results of this study showed that EPO has neuroprotective effects in the rat model of HE, possibly due to its anti-inflammatory and anti-oxidant properties. Complementary studies are required to clarify the exact mechanisms. AIMS Press 2019-04-29 /pmc/articles/PMC7179341/ /pubmed/32341967 http://dx.doi.org/10.3934/Neuroscience.2019.2.43 Text en © 2019 the Author(s), licensee AIMS Press This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
spellingShingle Research Article
Golshani, Moazameh
Basiri, Mohsen
Shabani, Mohammad
Aghaei, Iraj
Asadi-Shekaari, Majid
Effects of erythropoietin on bile duct ligation-induced neuro-inflammation in male rats
title Effects of erythropoietin on bile duct ligation-induced neuro-inflammation in male rats
title_full Effects of erythropoietin on bile duct ligation-induced neuro-inflammation in male rats
title_fullStr Effects of erythropoietin on bile duct ligation-induced neuro-inflammation in male rats
title_full_unstemmed Effects of erythropoietin on bile duct ligation-induced neuro-inflammation in male rats
title_short Effects of erythropoietin on bile duct ligation-induced neuro-inflammation in male rats
title_sort effects of erythropoietin on bile duct ligation-induced neuro-inflammation in male rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179341/
https://www.ncbi.nlm.nih.gov/pubmed/32341967
http://dx.doi.org/10.3934/Neuroscience.2019.2.43
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