Novel Steroidal 5α,8α-Endoperoxide Derivatives with Semicarbazone/Thiosemicarbazone Side-chain as Apoptotic Inducers through an Intrinsic Apoptosis Pathway: Design, Synthesis and Biological Studies

A series of novel steroidal 5α,8α-endoperoxide derivatives bearing semicarbazone (7a–g) or thiosemicarbazone (7h–k) side chain were designed, synthesized and evaluated for their cytotoxicities in four human cancer cell lines (HepG2, HCT-116, MCF-7, and A549) using the MTT assay in vitro. The results...

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Detalles Bibliográficos
Autores principales: Ma, Liwei, Wang, Haijun, Wang, Jing, Liu, Lei, Zhang, Song, Bu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179397/
https://www.ncbi.nlm.nih.gov/pubmed/32156024
http://dx.doi.org/10.3390/molecules25051209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179397/
https://www.ncbi.nlm.nih.gov/pubmed/32156024
http://dx.doi.org/10.3390/molecules25051209

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