Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada

Three new inositol angelate compounds (1–3) and two new tirucallane-type alkaloids (4 and 5) were isolated from the Amoora dasyclada, and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds 4...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Sheng-Xiang, Song, Cheng-Gang, Kuang, Yi, Liu, Bing, Zhang, Yan-Xin, Zhang, Ming-Zhe, Zhang, Chun-Ying, Ding, Gang, Qin, Jian-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179408/
https://www.ncbi.nlm.nih.gov/pubmed/32182779
http://dx.doi.org/10.3390/molecules25051222
_version_ 1783525649550409728
author Yang, Sheng-Xiang
Song, Cheng-Gang
Kuang, Yi
Liu, Bing
Zhang, Yan-Xin
Zhang, Ming-Zhe
Zhang, Chun-Ying
Ding, Gang
Qin, Jian-Chun
author_facet Yang, Sheng-Xiang
Song, Cheng-Gang
Kuang, Yi
Liu, Bing
Zhang, Yan-Xin
Zhang, Ming-Zhe
Zhang, Chun-Ying
Ding, Gang
Qin, Jian-Chun
author_sort Yang, Sheng-Xiang
collection PubMed
description Three new inositol angelate compounds (1–3) and two new tirucallane-type alkaloids (4 and 5) were isolated from the Amoora dasyclada, and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds 4 and 5 exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC(50) value at 8.4 and 13.2 μM. In addition, compounds 4 and 5 also showed remarkable growth inhibitory activity to Artemia salina larvae.
format Online
Article
Text
id pubmed-7179408
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71794082020-04-28 Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada Yang, Sheng-Xiang Song, Cheng-Gang Kuang, Yi Liu, Bing Zhang, Yan-Xin Zhang, Ming-Zhe Zhang, Chun-Ying Ding, Gang Qin, Jian-Chun Molecules Article Three new inositol angelate compounds (1–3) and two new tirucallane-type alkaloids (4 and 5) were isolated from the Amoora dasyclada, and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds 4 and 5 exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC(50) value at 8.4 and 13.2 μM. In addition, compounds 4 and 5 also showed remarkable growth inhibitory activity to Artemia salina larvae. MDPI 2020-03-09 /pmc/articles/PMC7179408/ /pubmed/32182779 http://dx.doi.org/10.3390/molecules25051222 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Sheng-Xiang
Song, Cheng-Gang
Kuang, Yi
Liu, Bing
Zhang, Yan-Xin
Zhang, Ming-Zhe
Zhang, Chun-Ying
Ding, Gang
Qin, Jian-Chun
Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada
title Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada
title_full Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada
title_fullStr Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada
title_full_unstemmed Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada
title_short Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada
title_sort cytotoxic activity of inositol angelates and tirucallane-type alkaloids from amoora dasyclada
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179408/
https://www.ncbi.nlm.nih.gov/pubmed/32182779
http://dx.doi.org/10.3390/molecules25051222
work_keys_str_mv AT yangshengxiang cytotoxicactivityofinositolangelatesandtirucallanetypealkaloidsfromamooradasyclada
AT songchenggang cytotoxicactivityofinositolangelatesandtirucallanetypealkaloidsfromamooradasyclada
AT kuangyi cytotoxicactivityofinositolangelatesandtirucallanetypealkaloidsfromamooradasyclada
AT liubing cytotoxicactivityofinositolangelatesandtirucallanetypealkaloidsfromamooradasyclada
AT zhangyanxin cytotoxicactivityofinositolangelatesandtirucallanetypealkaloidsfromamooradasyclada
AT zhangmingzhe cytotoxicactivityofinositolangelatesandtirucallanetypealkaloidsfromamooradasyclada
AT zhangchunying cytotoxicactivityofinositolangelatesandtirucallanetypealkaloidsfromamooradasyclada
AT dinggang cytotoxicactivityofinositolangelatesandtirucallanetypealkaloidsfromamooradasyclada
AT qinjianchun cytotoxicactivityofinositolangelatesandtirucallanetypealkaloidsfromamooradasyclada

Ejemplares similares