Liquid Chromatography–Tandem Mass Spectrometry for the Simultaneous Determination of Doxorubicin and its Metabolites Doxorubicinol, Doxorubicinone, Doxorubicinolone, and 7-Deoxydoxorubicinone in Mouse Plasma

Doxorubicin, an anthracycline antitumor antibiotic, acts as a cancer treatment by interfering with the function of DNA. Herein, liquid chromatography-tandem mass spectrometry was for the first time developed and validated for the simultaneous determination of doxorubicin and its major metabolites do...

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Detalles Bibliográficos
Autores principales: Choi, Won-Gu, Kim, Dong Kyun, Shin, Yongho, Park, Ria, Cho, Yong-Yeon, Lee, Joo Young, Kang, Han Chang, Lee, Hye Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179444/
https://www.ncbi.nlm.nih.gov/pubmed/32164308
http://dx.doi.org/10.3390/molecules25051254

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