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HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17

Cytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities and pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6-O-methyl-cha...

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Autores principales: Luo, Xiao-Wei, Gao, Cheng-Hai, Lu, Hu-Mu, Wang, Jia-Min, Su, Zi-Qi, Tao, Hua-Ming, Zhou, Xue-Feng, Yang, Bin, Liu, Yong-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179451/
https://www.ncbi.nlm.nih.gov/pubmed/32182966
http://dx.doi.org/10.3390/molecules25051237
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author Luo, Xiao-Wei
Gao, Cheng-Hai
Lu, Hu-Mu
Wang, Jia-Min
Su, Zi-Qi
Tao, Hua-Ming
Zhou, Xue-Feng
Yang, Bin
Liu, Yong-Hong
author_facet Luo, Xiao-Wei
Gao, Cheng-Hai
Lu, Hu-Mu
Wang, Jia-Min
Su, Zi-Qi
Tao, Hua-Ming
Zhou, Xue-Feng
Yang, Bin
Liu, Yong-Hong
author_sort Luo, Xiao-Wei
collection PubMed
description Cytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities and pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6-O-methyl-chaetoglobosin Q (1), were isolated from the coral-associated fungus Chaetomium globosum C2F17. Their structures were accomplished by extensive spectroscopic analysis combined with single-crystal X-ray crystallography and ECD calculations. Meanwhile, the structures and absolute configurations of the previously reported compounds 6, 12, and 13 were confirmed by single-crystal X-ray analysis for the first time. Chaetoglobosins E (6) and Fex (11) showed significant cytotoxicity against a panel of cancer cell lines, K562, A549, Huh7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4, with the IC(50) values ranging from 1.4 μM to 9.2 μM.
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spelling pubmed-71794512020-05-05 HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17 Luo, Xiao-Wei Gao, Cheng-Hai Lu, Hu-Mu Wang, Jia-Min Su, Zi-Qi Tao, Hua-Ming Zhou, Xue-Feng Yang, Bin Liu, Yong-Hong Molecules Article Cytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities and pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6-O-methyl-chaetoglobosin Q (1), were isolated from the coral-associated fungus Chaetomium globosum C2F17. Their structures were accomplished by extensive spectroscopic analysis combined with single-crystal X-ray crystallography and ECD calculations. Meanwhile, the structures and absolute configurations of the previously reported compounds 6, 12, and 13 were confirmed by single-crystal X-ray analysis for the first time. Chaetoglobosins E (6) and Fex (11) showed significant cytotoxicity against a panel of cancer cell lines, K562, A549, Huh7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4, with the IC(50) values ranging from 1.4 μM to 9.2 μM. MDPI 2020-03-09 /pmc/articles/PMC7179451/ /pubmed/32182966 http://dx.doi.org/10.3390/molecules25051237 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Luo, Xiao-Wei
Gao, Cheng-Hai
Lu, Hu-Mu
Wang, Jia-Min
Su, Zi-Qi
Tao, Hua-Ming
Zhou, Xue-Feng
Yang, Bin
Liu, Yong-Hong
HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17
title HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17
title_full HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17
title_fullStr HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17
title_full_unstemmed HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17
title_short HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17
title_sort hplc-dad-guided isolation of diversified chaetoglobosins from the coral-associated fungus chaetomium globosum c2f17
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179451/
https://www.ncbi.nlm.nih.gov/pubmed/32182966
http://dx.doi.org/10.3390/molecules25051237
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