Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction

This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53– Mouse double minute 2 homolog (MDM2) protein–protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding charac...

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Detalles Bibliográficos
Autores principales: Beloglazkina, Anastasia, Zyk, Nikolai, Majouga, Alexander, Beloglazkina, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179467/
https://www.ncbi.nlm.nih.gov/pubmed/32156064
http://dx.doi.org/10.3390/molecules25051211
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author Beloglazkina, Anastasia
Zyk, Nikolai
Majouga, Alexander
Beloglazkina, Elena
author_facet Beloglazkina, Anastasia
Zyk, Nikolai
Majouga, Alexander
Beloglazkina, Elena
author_sort Beloglazkina, Anastasia
collection PubMed
description This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53– Mouse double minute 2 homolog (MDM2) protein–protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding characteristics.
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spelling pubmed-71794672020-05-05 Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction Beloglazkina, Anastasia Zyk, Nikolai Majouga, Alexander Beloglazkina, Elena Molecules Review This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53– Mouse double minute 2 homolog (MDM2) protein–protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding characteristics. MDPI 2020-03-07 /pmc/articles/PMC7179467/ /pubmed/32156064 http://dx.doi.org/10.3390/molecules25051211 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Beloglazkina, Anastasia
Zyk, Nikolai
Majouga, Alexander
Beloglazkina, Elena
Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction
title Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction
title_full Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction
title_fullStr Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction
title_full_unstemmed Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction
title_short Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction
title_sort recent small-molecule inhibitors of the p53–mdm2 protein–protein interaction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179467/
https://www.ncbi.nlm.nih.gov/pubmed/32156064
http://dx.doi.org/10.3390/molecules25051211
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