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How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review
OBJECTIVES: SARS-CoV-2 infection has now a global resonance. Data on how COVID-19 is affecting immunocompromised patients are however few. With our study we aimed to systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Infection Association. Published by Elsevier Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179496/ https://www.ncbi.nlm.nih.gov/pubmed/32335173 http://dx.doi.org/10.1016/j.jinf.2020.04.026 |
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author | Minotti, Chiara Tirelli, Francesca Barbieri, Elisa Giaquinto, Carlo Donà, Daniele |
author_facet | Minotti, Chiara Tirelli, Francesca Barbieri, Elisa Giaquinto, Carlo Donà, Daniele |
author_sort | Minotti, Chiara |
collection | PubMed |
description | OBJECTIVES: SARS-CoV-2 infection has now a global resonance. Data on how COVID-19 is affecting immunocompromised patients are however few. With our study we aimed to systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in this special population. METHODS: A systematic review of literature was carried out to identify relevant articles, searching the EMBASE, Medline, and Google Scholar databases. Studies reporting data on pre-defined outcomes and related to immunosuppressed adults and children with SARS-CoV-2 were included. RESULTS: Sixteen relevant articles were identified with 110 immunosuppressed patients, mostly presenting cancer, along with transplantation and immunodeficiency. Cancer was more often associated with a more severe course, but not necessarily with a bad prognosis. Our data show that both children and adults with immunosuppression seem to have a favorable disease course, as compared to the general population. CONCLUSION: Immunosuppressed patients with COVID-19 seem to be few in relation to the overall figures, and to present a favorable outcome as compared to other comorbidities. This might be explained by a hypothetical protective role of a weaker immune response, determining a milder disease presentation and thus underdiagnosis. Nevertheless, surveillance on this special population should be encouraged. |
format | Online Article Text |
id | pubmed-7179496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The British Infection Association. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71794962020-04-24 How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review Minotti, Chiara Tirelli, Francesca Barbieri, Elisa Giaquinto, Carlo Donà, Daniele J Infect Review OBJECTIVES: SARS-CoV-2 infection has now a global resonance. Data on how COVID-19 is affecting immunocompromised patients are however few. With our study we aimed to systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in this special population. METHODS: A systematic review of literature was carried out to identify relevant articles, searching the EMBASE, Medline, and Google Scholar databases. Studies reporting data on pre-defined outcomes and related to immunosuppressed adults and children with SARS-CoV-2 were included. RESULTS: Sixteen relevant articles were identified with 110 immunosuppressed patients, mostly presenting cancer, along with transplantation and immunodeficiency. Cancer was more often associated with a more severe course, but not necessarily with a bad prognosis. Our data show that both children and adults with immunosuppression seem to have a favorable disease course, as compared to the general population. CONCLUSION: Immunosuppressed patients with COVID-19 seem to be few in relation to the overall figures, and to present a favorable outcome as compared to other comorbidities. This might be explained by a hypothetical protective role of a weaker immune response, determining a milder disease presentation and thus underdiagnosis. Nevertheless, surveillance on this special population should be encouraged. The British Infection Association. Published by Elsevier Ltd. 2020-07 2020-04-23 /pmc/articles/PMC7179496/ /pubmed/32335173 http://dx.doi.org/10.1016/j.jinf.2020.04.026 Text en © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Minotti, Chiara Tirelli, Francesca Barbieri, Elisa Giaquinto, Carlo Donà, Daniele How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review |
title | How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review |
title_full | How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review |
title_fullStr | How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review |
title_full_unstemmed | How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review |
title_short | How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review |
title_sort | how is immunosuppressive status affecting children and adults in sars-cov-2 infection? a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179496/ https://www.ncbi.nlm.nih.gov/pubmed/32335173 http://dx.doi.org/10.1016/j.jinf.2020.04.026 |
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