Cargando…

How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review

OBJECTIVES: SARS-CoV-2 infection has now a global resonance. Data on how COVID-19 is affecting immunocompromised patients are however few. With our study we aimed to systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in...

Descripción completa

Detalles Bibliográficos
Autores principales: Minotti, Chiara, Tirelli, Francesca, Barbieri, Elisa, Giaquinto, Carlo, Donà, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Infection Association. Published by Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179496/
https://www.ncbi.nlm.nih.gov/pubmed/32335173
http://dx.doi.org/10.1016/j.jinf.2020.04.026
_version_ 1783525669779537920
author Minotti, Chiara
Tirelli, Francesca
Barbieri, Elisa
Giaquinto, Carlo
Donà, Daniele
author_facet Minotti, Chiara
Tirelli, Francesca
Barbieri, Elisa
Giaquinto, Carlo
Donà, Daniele
author_sort Minotti, Chiara
collection PubMed
description OBJECTIVES: SARS-CoV-2 infection has now a global resonance. Data on how COVID-19 is affecting immunocompromised patients are however few. With our study we aimed to systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in this special population. METHODS: A systematic review of literature was carried out to identify relevant articles, searching the EMBASE, Medline, and Google Scholar databases. Studies reporting data on pre-defined outcomes and related to immunosuppressed adults and children with SARS-CoV-2 were included. RESULTS: Sixteen relevant articles were identified with 110 immunosuppressed patients, mostly presenting cancer, along with transplantation and immunodeficiency. Cancer was more often associated with a more severe course, but not necessarily with a bad prognosis. Our data show that both children and adults with immunosuppression seem to have a favorable disease course, as compared to the general population. CONCLUSION: Immunosuppressed patients with COVID-19 seem to be few in relation to the overall figures, and to present a favorable outcome as compared to other comorbidities. This might be explained by a hypothetical protective role of a weaker immune response, determining a milder disease presentation and thus underdiagnosis. Nevertheless, surveillance on this special population should be encouraged.
format Online
Article
Text
id pubmed-7179496
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The British Infection Association. Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71794962020-04-24 How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review Minotti, Chiara Tirelli, Francesca Barbieri, Elisa Giaquinto, Carlo Donà, Daniele J Infect Review OBJECTIVES: SARS-CoV-2 infection has now a global resonance. Data on how COVID-19 is affecting immunocompromised patients are however few. With our study we aimed to systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in this special population. METHODS: A systematic review of literature was carried out to identify relevant articles, searching the EMBASE, Medline, and Google Scholar databases. Studies reporting data on pre-defined outcomes and related to immunosuppressed adults and children with SARS-CoV-2 were included. RESULTS: Sixteen relevant articles were identified with 110 immunosuppressed patients, mostly presenting cancer, along with transplantation and immunodeficiency. Cancer was more often associated with a more severe course, but not necessarily with a bad prognosis. Our data show that both children and adults with immunosuppression seem to have a favorable disease course, as compared to the general population. CONCLUSION: Immunosuppressed patients with COVID-19 seem to be few in relation to the overall figures, and to present a favorable outcome as compared to other comorbidities. This might be explained by a hypothetical protective role of a weaker immune response, determining a milder disease presentation and thus underdiagnosis. Nevertheless, surveillance on this special population should be encouraged. The British Infection Association. Published by Elsevier Ltd. 2020-07 2020-04-23 /pmc/articles/PMC7179496/ /pubmed/32335173 http://dx.doi.org/10.1016/j.jinf.2020.04.026 Text en © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Minotti, Chiara
Tirelli, Francesca
Barbieri, Elisa
Giaquinto, Carlo
Donà, Daniele
How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review
title How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review
title_full How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review
title_fullStr How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review
title_full_unstemmed How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review
title_short How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review
title_sort how is immunosuppressive status affecting children and adults in sars-cov-2 infection? a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179496/
https://www.ncbi.nlm.nih.gov/pubmed/32335173
http://dx.doi.org/10.1016/j.jinf.2020.04.026
work_keys_str_mv AT minottichiara howisimmunosuppressivestatusaffectingchildrenandadultsinsarscov2infectionasystematicreview
AT tirellifrancesca howisimmunosuppressivestatusaffectingchildrenandadultsinsarscov2infectionasystematicreview
AT barbierielisa howisimmunosuppressivestatusaffectingchildrenandadultsinsarscov2infectionasystematicreview
AT giaquintocarlo howisimmunosuppressivestatusaffectingchildrenandadultsinsarscov2infectionasystematicreview
AT donadaniele howisimmunosuppressivestatusaffectingchildrenandadultsinsarscov2infectionasystematicreview