Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses

Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in viv...

Descripción completa

Detalles Bibliográficos
Autores principales: Ekins, Sean, Madrid, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179581/
https://www.ncbi.nlm.nih.gov/pubmed/32205350
http://dx.doi.org/10.1128/AAC.00440-20
_version_ 1783525676109791232
author Ekins, Sean
Madrid, Peter B.
author_facet Ekins, Sean
Madrid, Peter B.
author_sort Ekins, Sean
collection PubMed
description Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV).
format Online
Article
Text
id pubmed-7179581
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-71795812020-04-27 Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses Ekins, Sean Madrid, Peter B. Antimicrob Agents Chemother Antiviral Agents Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). American Society for Microbiology 2020-04-21 /pmc/articles/PMC7179581/ /pubmed/32205350 http://dx.doi.org/10.1128/AAC.00440-20 Text en Copyright © 2020 American Society for Microbiology. This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Antiviral Agents
Ekins, Sean
Madrid, Peter B.
Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses
title Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses
title_full Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses
title_fullStr Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses
title_full_unstemmed Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses
title_short Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses
title_sort tilorone, a broad-spectrum antiviral for emerging viruses
topic Antiviral Agents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179581/
https://www.ncbi.nlm.nih.gov/pubmed/32205350
http://dx.doi.org/10.1128/AAC.00440-20
work_keys_str_mv AT ekinssean tiloroneabroadspectrumantiviralforemergingviruses
AT madridpeterb tiloroneabroadspectrumantiviralforemergingviruses

Ejemplares similares