Effects of Tenofovir on the Single-Dose Pharmacokinetics of Intravenous Morinidazole in Healthy Chinese Subjects

The effects of multiple-dose administration of tenofovir disoproxil fumarate (TDF) on the pharmacokinetics of morinidazole (MOR) were compared in healthy subjects. MOR exposure was similar, with an area under the curve from 0 h to infinity (AUC(0-∞)) treatment ratio for MOR+TDF/MOR of 1.01 (90% conf...

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Detalles Bibliográficos
Autores principales: Wu, Guolan, Tang, Wenling, Lv, Duo, Wu, Lihua, Zhou, Huili, Yang, Xi, Zheng, Yunliang, Zhai, You, Shentu, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179596/
https://www.ncbi.nlm.nih.gov/pubmed/32152080
http://dx.doi.org/10.1128/AAC.02067-19
Descripción
Sumario:The effects of multiple-dose administration of tenofovir disoproxil fumarate (TDF) on the pharmacokinetics of morinidazole (MOR) were compared in healthy subjects. MOR exposure was similar, with an area under the curve from 0 h to infinity (AUC(0-∞)) treatment ratio for MOR+TDF/MOR of 1.01 (90% confidence interval, 0.97 to 1.06). No relevant differences were observed regarding plasma exposure of metabolites. Renal clearances of MOR and its metabolites were not affected by TDF. No unexpected safety or tolerability issues were observed.

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