Effects of Tenofovir on the Single-Dose Pharmacokinetics of Intravenous Morinidazole in Healthy Chinese Subjects

The effects of multiple-dose administration of tenofovir disoproxil fumarate (TDF) on the pharmacokinetics of morinidazole (MOR) were compared in healthy subjects. MOR exposure was similar, with an area under the curve from 0 h to infinity (AUC(0-∞)) treatment ratio for MOR+TDF/MOR of 1.01 (90% conf...

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Autores principales: Wu, Guolan, Tang, Wenling, Lv, Duo, Wu, Lihua, Zhou, Huili, Yang, Xi, Zheng, Yunliang, Zhai, You, Shentu, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179596/
https://www.ncbi.nlm.nih.gov/pubmed/32152080
http://dx.doi.org/10.1128/AAC.02067-19
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author Wu, Guolan
Tang, Wenling
Lv, Duo
Wu, Lihua
Zhou, Huili
Yang, Xi
Zheng, Yunliang
Zhai, You
Shentu, Jianzhong
author_facet Wu, Guolan
Tang, Wenling
Lv, Duo
Wu, Lihua
Zhou, Huili
Yang, Xi
Zheng, Yunliang
Zhai, You
Shentu, Jianzhong
author_sort Wu, Guolan
collection PubMed
description The effects of multiple-dose administration of tenofovir disoproxil fumarate (TDF) on the pharmacokinetics of morinidazole (MOR) were compared in healthy subjects. MOR exposure was similar, with an area under the curve from 0 h to infinity (AUC(0-∞)) treatment ratio for MOR+TDF/MOR of 1.01 (90% confidence interval, 0.97 to 1.06). No relevant differences were observed regarding plasma exposure of metabolites. Renal clearances of MOR and its metabolites were not affected by TDF. No unexpected safety or tolerability issues were observed.
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spelling pubmed-71795962020-04-27 Effects of Tenofovir on the Single-Dose Pharmacokinetics of Intravenous Morinidazole in Healthy Chinese Subjects Wu, Guolan Tang, Wenling Lv, Duo Wu, Lihua Zhou, Huili Yang, Xi Zheng, Yunliang Zhai, You Shentu, Jianzhong Antimicrob Agents Chemother Pharmacology The effects of multiple-dose administration of tenofovir disoproxil fumarate (TDF) on the pharmacokinetics of morinidazole (MOR) were compared in healthy subjects. MOR exposure was similar, with an area under the curve from 0 h to infinity (AUC(0-∞)) treatment ratio for MOR+TDF/MOR of 1.01 (90% confidence interval, 0.97 to 1.06). No relevant differences were observed regarding plasma exposure of metabolites. Renal clearances of MOR and its metabolites were not affected by TDF. No unexpected safety or tolerability issues were observed. American Society for Microbiology 2020-04-21 /pmc/articles/PMC7179596/ /pubmed/32152080 http://dx.doi.org/10.1128/AAC.02067-19 Text en Copyright © 2020 Wu et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Pharmacology
Wu, Guolan
Tang, Wenling
Lv, Duo
Wu, Lihua
Zhou, Huili
Yang, Xi
Zheng, Yunliang
Zhai, You
Shentu, Jianzhong
Effects of Tenofovir on the Single-Dose Pharmacokinetics of Intravenous Morinidazole in Healthy Chinese Subjects
title Effects of Tenofovir on the Single-Dose Pharmacokinetics of Intravenous Morinidazole in Healthy Chinese Subjects
title_full Effects of Tenofovir on the Single-Dose Pharmacokinetics of Intravenous Morinidazole in Healthy Chinese Subjects
title_fullStr Effects of Tenofovir on the Single-Dose Pharmacokinetics of Intravenous Morinidazole in Healthy Chinese Subjects
title_full_unstemmed Effects of Tenofovir on the Single-Dose Pharmacokinetics of Intravenous Morinidazole in Healthy Chinese Subjects
title_short Effects of Tenofovir on the Single-Dose Pharmacokinetics of Intravenous Morinidazole in Healthy Chinese Subjects
title_sort effects of tenofovir on the single-dose pharmacokinetics of intravenous morinidazole in healthy chinese subjects
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179596/
https://www.ncbi.nlm.nih.gov/pubmed/32152080
http://dx.doi.org/10.1128/AAC.02067-19
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