Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms

Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staph...

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Autores principales: Frapwell, C. J., Skipp, P. J., Howlin, R. P., Angus, E. M., Hu, Y., Coates, A. R. M., Allan, R. N., Webb, J. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Susceptibility
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179629/
https://www.ncbi.nlm.nih.gov/pubmed/32122902
http://dx.doi.org/10.1128/AAC.02073-19
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author Frapwell, C. J.
Skipp, P. J.
Howlin, R. P.
Angus, E. M.
Hu, Y.
Coates, A. R. M.
Allan, R. N.
Webb, J. S.
author_facet Frapwell, C. J.
Skipp, P. J.
Howlin, R. P.
Angus, E. M.
Hu, Y.
Coates, A. R. M.
Allan, R. N.
Webb, J. S.
author_sort Frapwell, C. J.
collection PubMed
description Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.
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spelling pubmed-71796292020-04-27 Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms Frapwell, C. J. Skipp, P. J. Howlin, R. P. Angus, E. M. Hu, Y. Coates, A. R. M. Allan, R. N. Webb, J. S. Antimicrob Agents Chemother Susceptibility Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections. American Society for Microbiology 2020-04-21 /pmc/articles/PMC7179629/ /pubmed/32122902 http://dx.doi.org/10.1128/AAC.02073-19 Text en Copyright © 2020 Frapwell et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Susceptibility
Frapwell, C. J.
Skipp, P. J.
Howlin, R. P.
Angus, E. M.
Hu, Y.
Coates, A. R. M.
Allan, R. N.
Webb, J. S.
Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms
title Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms
title_full Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms
title_fullStr Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms
title_full_unstemmed Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms
title_short Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms
title_sort antimicrobial activity of the quinoline derivative ht61 against staphylococcus aureus biofilms
topic Susceptibility
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179629/
https://www.ncbi.nlm.nih.gov/pubmed/32122902
http://dx.doi.org/10.1128/AAC.02073-19
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