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Molecular Mechanism of Selective Binding of NMS-P118 to PARP-1 and PARP-2: A Computational Perspective

The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors have been proven effective to potentiate both chemotherapeutic agents and radiotherapy. However, a major problem of most current PARP inhibitors is their lack of selectivity for PARP-1 and its closest isoform PARP-2. NMS-P118 is...

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Detalles Bibliográficos
Autores principales:	Wang, Ran, Cong, Yalong, Li, Mengxin, Bao, Jinxiao, Qi, Yifei, Zhang, John Z. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179655/ https://www.ncbi.nlm.nih.gov/pubmed/32373627 http://dx.doi.org/10.3389/fmolb.2020.00050

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