Cargando…

OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion

Optic Atrophy 1 (OPA1) has well-established roles in both mitochondrial fusion and apoptotic crista remodeling and is required for the maintenance and distribution of mitochondrial DNA (mtDNA), which are essential for energy metabolism. However, the relationship between OPA1 and mitochondrial metabo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Liang, Tang, Haite, Lin, Xiaobing, Wu, Yi, Zeng, Sheng, Pan, Yongzhang, Li, Yukun, Xiang, Ge, Lin, Yi-Fang, Zhuang, Shi-Mei, Song, Zhiyin, Jiang, Yiguo, Liu, Xingguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179665/ https://www.ncbi.nlm.nih.gov/pubmed/32373606 http://dx.doi.org/10.3389/fcell.2020.00180

Ejemplares similares

mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPR(mt))
por: Kenny, Timothy C., et al.
Publicado: (2017)

OPA1 Mutation and Late-Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability
por: Chen, Le, et al.
Publicado: (2012)

Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos
por: Otten, Auke B. C., et al.
Publicado: (2020)

Mutation of TWNK Gene Is One of the Reasons of Runting and Stunting Syndrome Characterized by mtDNA Depletion in Sex-Linked Dwarf Chicken
por: Hu, Bowen, et al.
Publicado: (2020)

mtDNA Heteroplasmy at the Core of Aging-Associated Heart Failure. An Integrative View of OXPHOS and Mitochondrial Life Cycle in Cardiac Mitochondrial Physiology
por: Elorza, Alvaro A., et al.
Publicado: (2021)

DNA Methylation of PGC-1α Is Associated With Elevated mtDNA Copy Number and Altered Urinary Metabolites in Autism Spectrum Disorder
por: Bam, Sophia, et al.
Publicado: (2021)

Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway
por: Jing, Ren, et al.
Publicado: (2020)

Opa1 Prevents Apoptosis and Cisplatin-Induced Ototoxicity in Murine Cochleae
por: Dong, Tingting, et al.
Publicado: (2021)

OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules
por: Yu-Wai-Man, Patrick, et al.
Publicado: (2010)

Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control
por: Xin, Ting, et al.
Publicado: (2020)

OPA1 Modulates Mitochondrial Ca(2+) Uptake Through ER-Mitochondria Coupling
por: Cartes-Saavedra, Benjamín, et al.
Publicado: (2022)

Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation
por: Stenberg, Simon, et al.
Publicado: (2022)

Association of circulating MtDNA with CVD in hemodialysis patients and in vitro effect of exogenous MtDNA on cardiac microvascular inflammation
por: Fan, Zhen, et al.
Publicado: (2023)

Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response
por: Gilkerson, Robert, et al.
Publicado: (2021)

Retraction: Opa1 reduces hypoxia-induced cardiomyocyte death by improving mitochondrial quality control
Publicado: (2022)

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
por: Suissa, Sarit, et al.
Publicado: (2009)

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions
por: Rebelo, Adriana P., et al.
Publicado: (2009)

Fusion of Wild-Type Mesoangioblasts with Myotubes of mtDNA Mutation Carriers Leads to a Proportional Reduction in mtDNA Mutation Load
por: Zelissen, Ruby, et al.
Publicado: (2023)

Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells
por: Ren, Lin, et al.
Publicado: (2020)

Where mtDNA is made
por: LeBrasseur, Nicole
Publicado: (2003)

Melanesian mtDNA Complexity
por: Friedlaender, Jonathan S., et al.
Publicado: (2007)

Mitochondria Targeted Antioxidant Significantly Alleviates Preeclampsia Caused by 11β-HSD2 Dysfunction via OPA1 and MtDNA Maintenance
por: Long, Jing, et al.
Publicado: (2022)

Role of Direct Repeat and Stem-Loop Motifs in mtDNA Deletions: Cause or Coincidence?
por: Lakshmanan, Lakshmi Narayanan, et al.
Publicado: (2012)

Genetic Diversity of mtDNA D-loop Polymorphisms in Laotian Native Fowl Populations
por: Kawabe, K., et al.
Publicado: (2014)

Cell-specific occupancy dynamics between the pioneer-like factor Opa/ZIC and Ocelliless/OTX regulate early head development in embryos
por: Fenelon, Kelli D., et al.
Publicado: (2023)

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
por: van Tienen, Florence, et al.
Publicado: (2019)

Mutation Screening of mtDNA Combined Targeted Exon Sequencing in a Cohort With Suspected Hereditary Optic Neuropathy
por: Li, Jian-Kang, et al.
Publicado: (2020)

Origins and Evolution of the Etruscans’ mtDNA
por: Ghirotto, Silvia, et al.
Publicado: (2013)

mtDNA in the Pathogenesis of Cardiovascular Diseases
por: Wang, Lili, et al.
Publicado: (2021)

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease
por: Nicholls, Thomas J., et al.
Publicado: (2014)

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats
por: Chimienti, Guglielmina, et al.
Publicado: (2019)

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
por: Filograna, R., et al.
Publicado: (2019)

Molecular Characterization of Sudanese and Southern Sudanese Chicken Breeds Using mtDNA D-Loop
por: Wani, Charles E., et al.
Publicado: (2014)

Genetic Diversity and Phylogenetic Evolution of Tibetan Sheep Based on mtDNA D-Loop Sequences
por: Liu, Jianbin, et al.
Publicado: (2016)

MELAS and Kearns–Sayre overlap syndrome due to the mtDNA m. A3243G mutation and large-scale mtDNA deletions
por: Yu, Nian, et al.
Publicado: (2016)

Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations
por: Tam, Zhi Yang, et al.
Publicado: (2015)

Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation
por: Diot, Alan, et al.
Publicado: (2018)

Evidence for a Fourteenth mtDNA-Encoded Protein in the Female-Transmitted mtDNA of Marine Mussels (Bivalvia: Mytilidae)
por: Breton, Sophie, et al.
Publicado: (2011)

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart
por: Chimienti, Guglielmina, et al.
Publicado: (2018)

UPR(mt) and coordinated UPR(ER) in type 2 diabetes
por: Kang, Zhanfang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k11b2ub4q4oijhnia72dnorbsm