Cargando…
Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes
We investigated the role of the inflammasome effector caspases-1 and -11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells (IECs). Salmonella burdens were significantly greater in the intestines of caspase-1/11 deficient (Casp1/11(−/−)), Casp1(−/−) and Ca...
Autores principales: | Crowley, Shauna M., Han, Xiao, Allaire, Joannie M., Stahl, Martin, Rauch, Isabella, Knodler, Leigh A., Vallance, Bruce A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179941/ https://www.ncbi.nlm.nih.gov/pubmed/32282854 http://dx.doi.org/10.1371/journal.ppat.1008498 |
Ejemplares similares
-
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
por: Lara-Tejero, Maria, et al.
Publicado: (2006) -
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
por: Broz, Petr, et al.
Publicado: (2012) -
Caspase-11 Non-canonical Inflammasomes in the Lung
por: Oh, Changhoon, et al.
Publicado: (2020) -
Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila
por: Gonçalves, Augusto V., et al.
Publicado: (2019) -
Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms
por: Broz, Petr, et al.
Publicado: (2013)