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Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways

The basal ganglia have been implicated in action selection and timing, but the relative contributions of the striatonigral (direct) and striatopallidal (indirect) pathways to these functions remain unclear. We investigated the effects of optogenetic stimulation of D1+ (direct) and A2A+ (indirect) ne...

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Autores principales: Bakhurin, Konstantin I, Li, Xiaoran, Friedman, Alexander D, Lusk, Nicholas A, Watson, Glenn DR, Kim, Namsoo, Yin, Henry H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180055/
https://www.ncbi.nlm.nih.gov/pubmed/32324535
http://dx.doi.org/10.7554/eLife.54831
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author Bakhurin, Konstantin I
Li, Xiaoran
Friedman, Alexander D
Lusk, Nicholas A
Watson, Glenn DR
Kim, Namsoo
Yin, Henry H
author_facet Bakhurin, Konstantin I
Li, Xiaoran
Friedman, Alexander D
Lusk, Nicholas A
Watson, Glenn DR
Kim, Namsoo
Yin, Henry H
author_sort Bakhurin, Konstantin I
collection PubMed
description The basal ganglia have been implicated in action selection and timing, but the relative contributions of the striatonigral (direct) and striatopallidal (indirect) pathways to these functions remain unclear. We investigated the effects of optogenetic stimulation of D1+ (direct) and A2A+ (indirect) neurons in the ventrolateral striatum in head-fixed mice on a fixed time reinforcement schedule. Direct pathway stimulation initiates licking, whereas indirect pathway stimulation suppresses licking and results in rebound licking after stimulation. Moreover, direct and indirect pathways also play distinct roles in timing. Direct pathway stimulation produced a resetting of the internal timing process, whereas indirect pathway stimulation transiently paused timing, and proportionally delayed the next bout of licking. Our results provide evidence for the continuous and opposing contributions of the direct and indirect pathways in the production and timing of reward-guided behavior.
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spelling pubmed-71800552020-04-27 Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways Bakhurin, Konstantin I Li, Xiaoran Friedman, Alexander D Lusk, Nicholas A Watson, Glenn DR Kim, Namsoo Yin, Henry H eLife Neuroscience The basal ganglia have been implicated in action selection and timing, but the relative contributions of the striatonigral (direct) and striatopallidal (indirect) pathways to these functions remain unclear. We investigated the effects of optogenetic stimulation of D1+ (direct) and A2A+ (indirect) neurons in the ventrolateral striatum in head-fixed mice on a fixed time reinforcement schedule. Direct pathway stimulation initiates licking, whereas indirect pathway stimulation suppresses licking and results in rebound licking after stimulation. Moreover, direct and indirect pathways also play distinct roles in timing. Direct pathway stimulation produced a resetting of the internal timing process, whereas indirect pathway stimulation transiently paused timing, and proportionally delayed the next bout of licking. Our results provide evidence for the continuous and opposing contributions of the direct and indirect pathways in the production and timing of reward-guided behavior. eLife Sciences Publications, Ltd 2020-04-23 /pmc/articles/PMC7180055/ /pubmed/32324535 http://dx.doi.org/10.7554/eLife.54831 Text en © 2020, Bakhurin et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Bakhurin, Konstantin I
Li, Xiaoran
Friedman, Alexander D
Lusk, Nicholas A
Watson, Glenn DR
Kim, Namsoo
Yin, Henry H
Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways
title Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways
title_full Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways
title_fullStr Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways
title_full_unstemmed Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways
title_short Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways
title_sort opponent regulation of action performance and timing by striatonigral and striatopallidal pathways
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180055/
https://www.ncbi.nlm.nih.gov/pubmed/32324535
http://dx.doi.org/10.7554/eLife.54831
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