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Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways
The basal ganglia have been implicated in action selection and timing, but the relative contributions of the striatonigral (direct) and striatopallidal (indirect) pathways to these functions remain unclear. We investigated the effects of optogenetic stimulation of D1+ (direct) and A2A+ (indirect) ne...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180055/ https://www.ncbi.nlm.nih.gov/pubmed/32324535 http://dx.doi.org/10.7554/eLife.54831 |
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author | Bakhurin, Konstantin I Li, Xiaoran Friedman, Alexander D Lusk, Nicholas A Watson, Glenn DR Kim, Namsoo Yin, Henry H |
author_facet | Bakhurin, Konstantin I Li, Xiaoran Friedman, Alexander D Lusk, Nicholas A Watson, Glenn DR Kim, Namsoo Yin, Henry H |
author_sort | Bakhurin, Konstantin I |
collection | PubMed |
description | The basal ganglia have been implicated in action selection and timing, but the relative contributions of the striatonigral (direct) and striatopallidal (indirect) pathways to these functions remain unclear. We investigated the effects of optogenetic stimulation of D1+ (direct) and A2A+ (indirect) neurons in the ventrolateral striatum in head-fixed mice on a fixed time reinforcement schedule. Direct pathway stimulation initiates licking, whereas indirect pathway stimulation suppresses licking and results in rebound licking after stimulation. Moreover, direct and indirect pathways also play distinct roles in timing. Direct pathway stimulation produced a resetting of the internal timing process, whereas indirect pathway stimulation transiently paused timing, and proportionally delayed the next bout of licking. Our results provide evidence for the continuous and opposing contributions of the direct and indirect pathways in the production and timing of reward-guided behavior. |
format | Online Article Text |
id | pubmed-7180055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-71800552020-04-27 Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways Bakhurin, Konstantin I Li, Xiaoran Friedman, Alexander D Lusk, Nicholas A Watson, Glenn DR Kim, Namsoo Yin, Henry H eLife Neuroscience The basal ganglia have been implicated in action selection and timing, but the relative contributions of the striatonigral (direct) and striatopallidal (indirect) pathways to these functions remain unclear. We investigated the effects of optogenetic stimulation of D1+ (direct) and A2A+ (indirect) neurons in the ventrolateral striatum in head-fixed mice on a fixed time reinforcement schedule. Direct pathway stimulation initiates licking, whereas indirect pathway stimulation suppresses licking and results in rebound licking after stimulation. Moreover, direct and indirect pathways also play distinct roles in timing. Direct pathway stimulation produced a resetting of the internal timing process, whereas indirect pathway stimulation transiently paused timing, and proportionally delayed the next bout of licking. Our results provide evidence for the continuous and opposing contributions of the direct and indirect pathways in the production and timing of reward-guided behavior. eLife Sciences Publications, Ltd 2020-04-23 /pmc/articles/PMC7180055/ /pubmed/32324535 http://dx.doi.org/10.7554/eLife.54831 Text en © 2020, Bakhurin et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Bakhurin, Konstantin I Li, Xiaoran Friedman, Alexander D Lusk, Nicholas A Watson, Glenn DR Kim, Namsoo Yin, Henry H Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways |
title | Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways |
title_full | Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways |
title_fullStr | Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways |
title_full_unstemmed | Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways |
title_short | Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways |
title_sort | opponent regulation of action performance and timing by striatonigral and striatopallidal pathways |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180055/ https://www.ncbi.nlm.nih.gov/pubmed/32324535 http://dx.doi.org/10.7554/eLife.54831 |
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