Cargando…

Patterned perturbation of inhibition can reveal the dynamical structure of neural processing

Perturbation of neuronal activity is key to understanding the brain’s functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in...

Descripción completa

Detalles Bibliográficos
Autores principales: Sadeh, Sadra, Clopath, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180056/
https://www.ncbi.nlm.nih.gov/pubmed/32073400
http://dx.doi.org/10.7554/eLife.52757
_version_ 1783525756676079616
author Sadeh, Sadra
Clopath, Claudia
author_facet Sadeh, Sadra
Clopath, Claudia
author_sort Sadeh, Sadra
collection PubMed
description Perturbation of neuronal activity is key to understanding the brain’s functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in identified target neurons to reveal more specific cortical function. Here, we argue that patterned perturbation of neurons is in fact necessary to reveal the specific dynamics of inhibitory stabilization, emerging in cortical networks with strong excitatory and inhibitory functional subnetworks, as recently reported in mouse visual cortex. We propose a specific perturbative signature of these networks and investigate how this can be measured under different experimental conditions. Functionally, rapid spontaneous transitions between selective ensembles of neurons emerge in such networks, consistent with experimental results. Our study outlines the dynamical and functional properties of feature-specific inhibitory-stabilized networks, and suggests experimental protocols that can be used to detect them in the intact cortex.
format Online
Article
Text
id pubmed-7180056
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-71800562020-04-27 Patterned perturbation of inhibition can reveal the dynamical structure of neural processing Sadeh, Sadra Clopath, Claudia eLife Neuroscience Perturbation of neuronal activity is key to understanding the brain’s functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in identified target neurons to reveal more specific cortical function. Here, we argue that patterned perturbation of neurons is in fact necessary to reveal the specific dynamics of inhibitory stabilization, emerging in cortical networks with strong excitatory and inhibitory functional subnetworks, as recently reported in mouse visual cortex. We propose a specific perturbative signature of these networks and investigate how this can be measured under different experimental conditions. Functionally, rapid spontaneous transitions between selective ensembles of neurons emerge in such networks, consistent with experimental results. Our study outlines the dynamical and functional properties of feature-specific inhibitory-stabilized networks, and suggests experimental protocols that can be used to detect them in the intact cortex. eLife Sciences Publications, Ltd 2020-02-19 /pmc/articles/PMC7180056/ /pubmed/32073400 http://dx.doi.org/10.7554/eLife.52757 Text en © 2020, Sadeh and Clopath http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Sadeh, Sadra
Clopath, Claudia
Patterned perturbation of inhibition can reveal the dynamical structure of neural processing
title Patterned perturbation of inhibition can reveal the dynamical structure of neural processing
title_full Patterned perturbation of inhibition can reveal the dynamical structure of neural processing
title_fullStr Patterned perturbation of inhibition can reveal the dynamical structure of neural processing
title_full_unstemmed Patterned perturbation of inhibition can reveal the dynamical structure of neural processing
title_short Patterned perturbation of inhibition can reveal the dynamical structure of neural processing
title_sort patterned perturbation of inhibition can reveal the dynamical structure of neural processing
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180056/
https://www.ncbi.nlm.nih.gov/pubmed/32073400
http://dx.doi.org/10.7554/eLife.52757
work_keys_str_mv AT sadehsadra patternedperturbationofinhibitioncanrevealthedynamicalstructureofneuralprocessing
AT clopathclaudia patternedperturbationofinhibitioncanrevealthedynamicalstructureofneuralprocessing