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Patterned perturbation of inhibition can reveal the dynamical structure of neural processing
Perturbation of neuronal activity is key to understanding the brain’s functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180056/ https://www.ncbi.nlm.nih.gov/pubmed/32073400 http://dx.doi.org/10.7554/eLife.52757 |
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author | Sadeh, Sadra Clopath, Claudia |
author_facet | Sadeh, Sadra Clopath, Claudia |
author_sort | Sadeh, Sadra |
collection | PubMed |
description | Perturbation of neuronal activity is key to understanding the brain’s functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in identified target neurons to reveal more specific cortical function. Here, we argue that patterned perturbation of neurons is in fact necessary to reveal the specific dynamics of inhibitory stabilization, emerging in cortical networks with strong excitatory and inhibitory functional subnetworks, as recently reported in mouse visual cortex. We propose a specific perturbative signature of these networks and investigate how this can be measured under different experimental conditions. Functionally, rapid spontaneous transitions between selective ensembles of neurons emerge in such networks, consistent with experimental results. Our study outlines the dynamical and functional properties of feature-specific inhibitory-stabilized networks, and suggests experimental protocols that can be used to detect them in the intact cortex. |
format | Online Article Text |
id | pubmed-7180056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-71800562020-04-27 Patterned perturbation of inhibition can reveal the dynamical structure of neural processing Sadeh, Sadra Clopath, Claudia eLife Neuroscience Perturbation of neuronal activity is key to understanding the brain’s functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in identified target neurons to reveal more specific cortical function. Here, we argue that patterned perturbation of neurons is in fact necessary to reveal the specific dynamics of inhibitory stabilization, emerging in cortical networks with strong excitatory and inhibitory functional subnetworks, as recently reported in mouse visual cortex. We propose a specific perturbative signature of these networks and investigate how this can be measured under different experimental conditions. Functionally, rapid spontaneous transitions between selective ensembles of neurons emerge in such networks, consistent with experimental results. Our study outlines the dynamical and functional properties of feature-specific inhibitory-stabilized networks, and suggests experimental protocols that can be used to detect them in the intact cortex. eLife Sciences Publications, Ltd 2020-02-19 /pmc/articles/PMC7180056/ /pubmed/32073400 http://dx.doi.org/10.7554/eLife.52757 Text en © 2020, Sadeh and Clopath http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Sadeh, Sadra Clopath, Claudia Patterned perturbation of inhibition can reveal the dynamical structure of neural processing |
title | Patterned perturbation of inhibition can reveal the dynamical structure of neural processing |
title_full | Patterned perturbation of inhibition can reveal the dynamical structure of neural processing |
title_fullStr | Patterned perturbation of inhibition can reveal the dynamical structure of neural processing |
title_full_unstemmed | Patterned perturbation of inhibition can reveal the dynamical structure of neural processing |
title_short | Patterned perturbation of inhibition can reveal the dynamical structure of neural processing |
title_sort | patterned perturbation of inhibition can reveal the dynamical structure of neural processing |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180056/ https://www.ncbi.nlm.nih.gov/pubmed/32073400 http://dx.doi.org/10.7554/eLife.52757 |
work_keys_str_mv | AT sadehsadra patternedperturbationofinhibitioncanrevealthedynamicalstructureofneuralprocessing AT clopathclaudia patternedperturbationofinhibitioncanrevealthedynamicalstructureofneuralprocessing |