Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila

Planar cell polarity (PCP) and neural tube defects (NTDs) are linked, with a subset of NTD patients found to harbor mutations in PCP genes, but there is limited data on whether these mutations disrupt PCP signaling in vivo. The core PCP gene Van Gogh (Vang), Vangl1/2 in mammals, is the most specific...

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Detalles Bibliográficos
Autores principales: Humphries, Ashley C, Narang, Sonali, Mlodzik, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180057/
https://www.ncbi.nlm.nih.gov/pubmed/32234212
http://dx.doi.org/10.7554/eLife.53532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180057/
https://www.ncbi.nlm.nih.gov/pubmed/32234212
http://dx.doi.org/10.7554/eLife.53532

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